After a rough start to her Australian Open career, world No. 1 Ashleigh Barty has found more success in recent years. The 25-year-old followed three first-round exits and a pair of third-round defeats with three consecutive quarterfinal appearances in the grand slam tournament in her homeland. The top-seeded Barty participates in the round of eight for a fourth straight year when she takes on the 21st-seeded Jessica Pegula on Tuesday in the 2022 Australian Open women's singles quarterfinals. Barty has advanced to the semifinals of the tournament just once, while Pegula is making the first grand slam quarterfinal appearance of her career.

Barty vs. Pegula is scheduled for 3 a.m. ET on Tuesday. The latest Pegula vs. Barty odds from Caesars Sportsbook list Barty as the -700 favorite (risk $700 to win $100), while Pegula is a +450 underdog. There are a variety of other Barty vs. Pegula picks on the board such as total match games, with the over-under set at 19.5. Before making any 2022 Australian Open women's quarterfinals picks, you need to check out the 2022 Australian Open predictions and betting advice from elite tennis handicapper Gavin Mair.

A renowned women's tennis handicapper, Mair has cashed in huge in the past. In the 2020 French Open, Mair picked Iga Swiatek to win (-163) and win in straight sets (+140), and he was right on both counts.

He also called unseeded Jelena Ostapenko (80-1) winning the 2017 French Open, Naomi Osaka (32-1) winning the 2018 U.S. Open and Bianca Andreescu (20-1) winning the 2019 U.S. Open.

Now, Mair has broken down the latest 2022 Australian Open women's quarterfinals odds and released his coveted best bets for Barty vs. Pegula. He's sharing all of his Australian Open picks and expert tennis analysis at SportsLine.

Ashleigh Barty vs. Jessica Pegula preview

Barty is attempting to become the first Australian woman to win this tournament since 1978, when Chris O'Neil defeated American Betsy Nagelsen for her only career grand slam title. Barty is seeking her third after having won the 2019 French Open and Wimbledon last year. Her only quarterfinal victory in the Australian Open came in 2020 against Petra Kvitova.

Amanda Anisimova gave Barty her toughest test in the tournament thus far but still lasted only 74 minutes, losing 6-4, 6-3 in the fourth round. Barty dropped only three games over the first two matches and knocked off No. 30 seed Camila Giorgi 6-2, 6-3 in the third round. She had similar ease in her only career matchup against Pegula, posting a 6-3, 6-3 victory in the first round of the 2019 French Open.

Pegula made her first quarterfinal appearance in a grand slam last year in Melbourne and got off to a strong start against Jennifer Brady but eventually succumbed, 6-4, 2-6, 1-6. The 27-year-old American returns to the round of eight after pulling off a 7-6 (7-0), 6-3 upset against the fifth-seeded and world No. 8 Maria Sakkari. The victory marked the eighth time in her career that Pegula has defeated an opponent ranked in the top 10, with the first coming in this tournament last year (Elina Svitolina, fourth round).

How to make Barty vs. Pegula picks

Is Barty set to reach the semifinals for the second time in three years, or is Pegula positioned to pull off another upset? Mair has released confident picks on the winner, as well as advice on match betting for the 2022 Australian Open. Make sure you check out Mair's predictions and analysis before making any Australian Open 2022 picks of your own for the women's quarterfinals.

Who wins Barty vs. Pegula in the 2022 Australian Open women's singles quarterfinal? And what match pick should you be all over? Visit SportsLine now to see Gavin Mair's best bets for Pegula vs. Barty, all from the acclaimed expert who has called three long-shot winners of Grand Slam women's titles since 2017, and find out.