Top-seeded Novak Djokovic aims for his 11th consecutive semifinal appearance when he faces No. 10 seed Jannik Sinner in a 2022 Wimbledon men's quarterfinal match at The All England Lawn Tennis and Croquet Club in London on Tuesday. The 35-year-old Djokovic is the three-time defending champion of this tournament and has six overall Wimbledon titles, two behind all-time leader Roger Federer. Sinner, a 20-year-old Italian, has reached the quarterfinals of a Grand Slam event for the third time in his brief career and second this year. The match is set to begin at 8:30 a.m. ET.

Djokovic is the clear -800 favorite (risk $800 to win $100) to win in the latest Djokovic vs. Sinner odds from Caesars Sportsbook, while Sinner is a +500 underdog. You also can pick whether or not Djokovic will cover the 6.5-game spread and how many games the match will last, as the over-under is set at 34.5 in the 2022 Wimbledon odds. Before making any Sinner vs. Djokovic picks, you need to see the Wimbledon 2022 predictions from SportsLine tennis handicapper Sean Calvert.

Calvert is the renowned tennis handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1 odds. In 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1, among many stunning calls. Anyone following his picks is way up.

Now, Calvert has scrutinized the latest Wimbledon 2022 odds and released his coveted best bets for Djokovic vs Sinner. He's sharing his expert tennis picks and analysis at SportsLine.

Djokovic vs. Sinner preview

Since retiring in the second set of his quarterfinal match against Tomas Berdych in 2017 due to an elbow injury, Djokovic has won 25 straight matches at Wimbledon. The Serb, who was ousted by Rafael Nadal in the quarters of the French Open on May 31, remains in search of his 21st career Grand Slam title. He currently is tied with Federer for second-most, two behind Nadal. Djokovic got past wild card Tim van Rijthoven 6-2, 4-6, 6-1, 6-2 on Sunday, marking the second time in four matches of this tournament he was stretched to four sets.

Djokovic's only previous meeting with Sinner came in Monaco last year, when he recorded a 6-4, 6-2 victory at the Monte-Carlo Masters. Sinner, who lost to Stefanos Tsitsipas in straight sets in the Australian Open quarterfinals earlier back in January, made a shocking appearance in the quarters of the 2020 French Open but was dispatched by Nadal in three sets. He set up this meeting with Djokovic by knocking off fifth-seeded Spaniard Carlos Alcaraz 6-1, 6-4, 6-7 (8-10), 6-3 on Sunday.

How to make Djokovic vs. Sinner picks

Calvert is leaning for the match to go over 34.5 total games, and he also has a best bet for this matchup that returns almost 3-1. Be sure to check out Calvert's expert picks at SportsLine.

What is the best bet for Djokovic vs. Sinner in the 2022 Wimbledon men's quarterfinal? Visit SportsLine now to see Sean Calvert's best bets for Sinner vs. Djokovic, all from the famed tennis handicapper who called Wawrinka winning the 2014 Australian Open at 60-1, and find out.