Getty Images

The No. 21 Seton Hall Pirates will take on the Ohio State Buckeyes at 6 p.m. ET Monday at Suncoast Credit Union Arena. Seton Hall (3-0) missed out on the NCAA Tournament last year, while Ohio State (3-1) was knocked out in the first round of last year's tourney. The winner of this game will then advance to the 2021 Fort Myers Tip-Off championship game on Wednesday.

The Pirates are favored by 2.5 points in the latest Seton Hall vs. Ohio State odds from Caesars Sportsbook, and the over-under is set at 137. Before entering any Ohio State vs. Seton Hall picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,100 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Ohio State vs. Seton Hall. You can head to SportsLine to see its picks. Here are several college basketball odds for Seton Hall vs. Ohio State:

  • Ohio State vs. Seton Hall spread: Pirates -2.5
  • Ohio State vs. Seton Hall over-under: 137 points

What you need to know about Ohio State

After winning their first three games, the Buckeyes suffered their first defeat on Thursday when they fell to Xavier 71-65. Ohio State struggled with putting the ball into the hoop as it shot just 37.7 percent after connecting on 49.4 percent over its first three games. E.J. Liddell led the Buckeyes with 17 points but he was the only starter with more than seven points.

Liddell was first team All-Big Ten last year and is on the Preseason Wooden Award watch list this year. He ranks second in the conference with 21.0 points per game while leading the Big Ten with 3.5 blocks per contest. Liddell had a career-high of eight blocks vs. Xavier and has 14 of the Buckeyes' 24 blocks on the season.

What you need to know about Seton Hall

The Pirates are coming off an impressive 67-65 victory over the No. 4 Michigan Wolverines on Tuesday. Jared Rhoden's 16 points led Seton Hall and he also added five rebounds, two assists and two steals. But the real star for the Pirates was their bench as the reserves scored 37 points compared to Michigan getting nine points from its bench.

Seton Hall is well balanced with four players averaging in double-figures and another three players averaging at least 9.0 PPG. Sixth-year senior Bryce Aiken leads the way with 12.3 points per game and is shooting a blistering 54.5 percent from beyond the arc. Tyrese Samuel is coming off the bench to average 9.7 points and 7.3 rebounds per game, while also ranking sixth in the Big East with 1.7 blocks per contest.

How to make Seton Hall vs. Ohio State picks

The model has simulated Ohio State vs. Seton Hall 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Seton Hall vs. Ohio State? And which side of the spread hits 60 percent of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that is up nearly $2,100 on its college basketball picks the last five years, and find out.