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The fifth-ranked Southern California Trojans and the Stanford Cardinal are set to square off in a Pac-12 matchup at 5 p.m. ET on Tuesday at Maples Pavilion. Stanford is 8-4 overall and 6-0 at home, while the Trojans are 13-0 overall and 4-0 on the road. Southern California returned from a two-week pause with a 77-63 win at California last Thursday. 

The Trojans are favored by six points in the latest Stanford vs. USC odds from Caesars Sportsbook, while the over-under is set at 139. Before entering any USC vs. Stanford picks, you'll want to see the college basketball predictions from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Stanford vs. Southern California. You can head to SportsLine to see its picks. Here are several college basketball odds for Stanford vs. USC:

  • Stanford vs. USC spread: Stanford +6
  • Stanford vs. USC over-under: 139 points
Featured Game | Stanford Cardinal vs. USC Trojans

What you need to know about Stanford

Stanford will be returning to the court for the first time since Dec. 23 when it picked up a 79-76 win over Liberty at the Diamond Head Classic in Honolulu. The Cardinal had their following games either canceled or postponed due to COVID-19 issues. They were originally scheduled to play Southern California on Saturday. 

Senior forward Jaiden Delaire leads Stanford with 12.3 points and 4.8 rebounds per game. Freshman forward Harrison Ingram is adding 12.2 points, 6.9 rebounds and a team-high 3.1 assists. Stanford has covered the spread in four of its last five games and is on a six-game home winning streak. 

What you need to know about USC

USC returned from a COVID-19 pause that lasted more than two weeks with a 77-63 win over California last Thursday. The Trojans are off to their best start since 2016-17, going unbeaten in their first 13 games. They have relied on a defense that ranks No. 17 nationally in 3-point percentage (27.5). 

Their scoring has been balanced, as four Trojans are averaging in double figures. Junior forward Isaiah Mobley leads the way with 15.3 points and 9.5 rebounds per game, while senior forward Chevez Goodwin is scoring 13.1 points. Southern California has covered the spread in four of its last five games against Stanford. 

How to make Stanford vs. USC picks

The model has simulated Stanford vs. USC 10,000 times and the results are in. We can tell you that the model is leaning over, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You can only see the pick at SportsLine.

So who wins USC vs. Stanford? And which side of the spread hits almost 60 percent of the time? Visit SportsLine now to find out, all from the model that has crushed its college basketball picks.