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The Philadelphia 76ers will take on the Chicago Bulls at 7 p.m. ET on Wednesday at the Wells Fargo Center. The Sixers are 5-2 overall and 3-1 at home, while Chicago is 6-1 overall and 3-0 on the road. Philadelphia scored a 113-103 win over Portland on Monday. Meanwhile, Chicago beat the Boston Celtics 128-114 in its last outing.

The Sixers have won the last seven games between the teams. Philadelphia is favored by two points in the latest Sixers vs. Bulls odds from Caesars Sportsbook, and the over-under is set at 215.5. Before entering any Bulls vs. Sixers picks, you'll want to see the NBA predictions from the advanced computer model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned almost $9,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model finished up almost $600 on its top-rated picks last season and entered Week 3 of the 2021-22 NBA season on a stunning 106-71 roll on top-rated NBA picks against the spread. Anyone following it has seen huge returns.

Now, the model has set its sights on Sixers vs. Bulls. You can head to SportsLine to see its picks. Here are several NBA betting lines for Sixers vs. Bulls:

  • Sixers vs. Bulls spread: Sixers -2
  • Sixers vs. Bulls over-under: 215.5 points
Featured Game | Philadelphia 76ers vs. Chicago Bulls

What you need to know about the Sixers

Andre Drummond posted a double-double with 15 boards and 14 points along with seven assists on Monday. Seth Curry scored 23 points. Joel Embiid was rested and Tobias Harris was out due to health and safety protocols. Danny Green (hamstring) left the win over Portland in the third quarter, but Philadelphia prevailed despite being short-handed. 

Georges Niang added 21 points on Monday. The Sixers have won three consecutive games. Harris and Green are out for Wednesday's game.  

What you need to know about the Bulls

Chicago overcame a 19-point third-quarter deficit and trailed by 14 points at the end of three quarters in the win over Boston. The Bulls scored the first 12 points of the fourth quarter. DeMar DeRozan finished with 37 points. Chicago scored 39 of the game's final 50 points. 

DeRozan and Zach LaVine are the only teammates to have six games of 20-plus points this season. Alex Caruso ranks third in the league with 18 steals. Nikola Vucevic has six double-doubles so far this season. 

How to make Sixers vs. Bulls picks

The model has simulated Sixers vs. Bulls 10,000 times and the results are in. We can tell you that the model is leaning over, and it also has generated a pick that hits in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Sixers vs. Bulls? And which side of the spread hits in over 50 percent of simulations? Visit SportsLine now to find out which side of the Sixers vs. Bulls spread you need to jump on Wednesday, all from the model that has crushed its NBA picks, and find out.