The Florida Gators and the No. 12 LSU Tigers are set to square off in an SEC showdown at 7 p.m. ET on Wednesday at the Stephen C. O'Connell Center. The Gators are 9-5 overall and 6-2 at home, while LSU is 14-1 overall and 0-1 on the road. LSU is coming off consecutive victories over ranked opponents in Kentucky and Tennessee

The Gators are favored by 2.5-points in the latest Florida vs. LSU odds from Caesars Sportsbook, while the over-under is set at 138.5. Before entering any LSU vs. Florida picks, you'll want to see the college basketball predictions from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Florida vs. LSU. You can head to SportsLine to see its picks. Here are several college basketball odds for Florida vs. LSU:

  • Florida vs. LSU spread: Florida -2.5
  • Florida vs. LSU over-under: 138.5 points
Featured Game | Florida Gators vs. LSU Tigers

What you need to know about Florida

Florida will be looking to bounce back following its loss at Auburn on Saturday. The Gators trailed by as many as 13 points, but they rallied to trim the deficit to one point late in the second half. They were unable to take the lead, though, eventually conceding in an 85-73 decision. 

The Gators have lost five of their past eight games and are 0-2 in SEC play for the first time since 2009-10. Senior forward Colin Castleton leads Florida with 15.6 points and 9.2 rebounds per game, while senior guard Phlandrous Fleming Jr. is scoring 10.6 points. The Gators have covered the spread in four of their last five home games against LSU. 

What you need to know about LSU

LSU has faced three straight ranked opponents to open conference play. The Tigers came up short at Auburn in their SEC opener, but they have responded with wins over Kentucky and Tennessee. Star guard Xavier Pinson sprained his MCL in the win over the Volunteers, so he is going to miss Wednesday's game.  

Pinson is the team's third-leading scorer and top assist man, averaging 10.9 points and 4.7 assists. Sophomore forward Tari Eason is scoring 16.2 points and is grabbing 7.6 rebounds. LSU has now covered the spread in 16 of its last 20 games dating back to last season. 

How to make Florida vs. LSU picks

The model has simulated Florida vs. LSU 10,000 times and the results are in. We can tell you that the model is leaning over, and it's also generated a point-spread pick that is hitting in 70 percent of simulations. You can only see the pick at SportsLine.

So who wins LSU vs. Florida? And which side of the spread covers 70 percent of the time? Visit SportsLine now to find out, all from the model that has crushed its college basketball picks.