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The Big Ten opens its conference play with a prime matchup between the No. 2 Purdue Boilermakers and the undefeated Iowa Hawkeyes on Friday night at 9 p.m. ET at Mackey Arena. Iowa is coming off a thrilling one-point win at Virginia on Monday, while Purdue is coming off of a 28-point win over Florida State and defeated Omaha by 57 points the game before that on November 26. Purdue center Zach Edey has led the Boilermakers this season with 16.9 points and 7.1 rebounds per game.

Keegan Murray has made a big leap for the Hawkeyes this season as their top offensive playmaker and has averaged 24.6 points and 8.9 rebounds for Iowa. The Boilermakers are favored by 11.5 points in the latest Purdue vs. Iowa odds from Caesars Sportsbook, and the over-under is set at 160.5. Before entering any Iowa vs. Purdue picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,100 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Purdue vs. Iowa. You can head to SportsLine to see its picks. Here are several college basketball odds for Purdue vs. Iowa:

  • Purdue vs. Iowa spread: Purdue -12.5
  • Purdue vs. Iowa over-under: 159.5 points
Featured Game | Purdue Boilermakers vs. Iowa Hawkeyes

What you need to know about Iowa

Iowa had won all of its previous games by double-digits prior to its last game against Virginia, which it managed to win on Friday by a single point, 75-74. Jordan Bohannon shot 6-for-9 from beyond the arc and finished with 20 points, while Murray added 18 points along with nine boards. Bohannon is part of a trio players that average 11 points per game, joined by Kris Murray and Patrick McCaffery.

Iowa beat Purdue during the regular season last year, but had a player of the year candidate on the roster in Luke Garza. This season, one of the Hawkeyes' strengths is their 3-point shooting. The Hawkeyes have hit 38 percent of their shots from distance, but Purdue could make that difficult on them on Friday, as the Boilermakers have allowed opponents to hit just 30 percent from beyond the arc.

What you need to know about Purdue

Everything went Purdue's way against the Florida State Seminoles on Tuesday as the Boilermakers made off with a 93-65 win. Five players on Purdue scored in the double digits: Guard Jaden Ivey (18 points), guard Brandon Newman (13), guard Isaiah Thompson (12), Edey (12), and guard Sasha Stefanovic (11).

The Boilermakers have been especially disciplined on defense this season and only average 12.9 personal fouls per game. That has resulted in opponents taking just 10.4 free throws per game, which is the fifth-lowest mark in all of college basketball. Meanwhile, the Boilermakers have the highest 3-point percentage in the country, at 44.2 percent this season. Stefanovic has led their attack from distance, and has made 46.8 percent of his 3-point attempts in 2021.

How to make Iowa vs. Purdue picks

The model is leaning under on the total, and it's also generated a point-spread pick that is hitting in well over 70 percent of simulations. You can only see the pick at SportsLine.

Who wins Purdue vs. Iowa? And which side of the spread hits well over 70 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks to find out.