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The Syracuse Orange will take on the Indiana Hoosiers at 7 p.m. ET on Tuesday at the Carrier Dome as part of the 2021 ACC/Big Ten Challenge. The Orange are 3-3 overall and 2-1 at home, while IU is 6-0 overall and 0-0 on the road. They're two of the most successful programs in the history of college basketball and famously played each other in the 1987 NCAA Tournament championship, but they haven't had a lot of recent history against each other.

Syracuse is 2-4 against the spread on the season, while Indiana is 4-2 against the number. The Hoosiers are favored by 3.5 points in the latest Syracuse vs. Indiana odds from Caesars Sportsbook and the over-under is set at 147.5. Before entering any Indiana vs. Syracuse picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,100 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Syracuse vs. Indiana. You can head to SportsLine to see its picks. Here are several college basketball odds for Indiana vs. Syracuse:

  • Syracuse vs. Indiana spread: Indiana -3.5
  • Syracuse vs. Indiana over-under: 147.5 points
Featured Game | Syracuse Orange vs. Indiana Hoosiers

What you need to know about Syracuse

Syracuse lost 89-68 against the Auburn Tigers this past Friday. A silver lining for Syracuse was the play of center Jesse Edwards, who had 17 points in addition to six boards. The third-year center from the Netherlands gives the Orange an interior presence to help space the floor with several shooters on the outside and he's also a strong rim protector at the other end (2.7 bpg).

Head coach Jim Boeheim's sons Buddy and Jimmy are both serious contributors as well, with Buddy Boeheim averaging 20.0 points per game in his fourth year in the program while Jimmy Boeheim is averaging 12.3 points and 6.7 rebounds in his first season after transferring from Cornell. Getting that pair going will be critical for Syracuse's success.

What you need to know about Indiana

Meanwhile, IU didn't have too much trouble with the Marshall Thundering Herd at home this past Saturday as it won 90-79. Forward Trayce Jackson-Davis took over for IU, finishing with 43 points (a whopping 48 percent ofits total) along with five blocks and five rebounds.

Jackson-Davis is an accomplished interior scorer who already crossed the 1,000-point mark for his career in just his third season on campus. He's averaging 20.5 points, 7.7 rebounds and 3.8 blocks per game this season and is now averaging 16.5 points, 8.6 rebounds and 1.8 blocks for his career. Jackson-Davis will have a considerable strength advantage down low and Syracuse's ability to handle him without getting into foul trouble to avoid having an already short eight-man rotation shortened will be key.

How to make Indiana vs. Syracuse picks

The model is leaning under on the total and it's also generated a point-spread pick that is hitting in nearly 70 percent of simulations. You can only see the pick at SportsLine.

So who wins Indiana vs. Syracuse? And which side of the spread hits nearly 70 percent of the time? Visit SportsLine now to find out, all from the red-hot model that has crushed its college basketball picks.