Get ready for a Pac-12 battle on Wednesday as the UCLA Bruins and the No. 25 Oregon Ducks will face off at 3 p.m. ET at Matthew Knight Arena. Oregon is 6-1 overall and 4-0 at home, while UCLA is 5-2 overall and 0-1 on the road. The Bruins are 5-0 against the spread in their last five games following an ATS loss. The Ducks, meanwhile, are 4-1 against the spread in their last five home games when playing a team with a losing road record.

The Ducks are favored by 2.5-points in the latest Oregon vs. UCLA odds from William Hill Sportsbook, and the over-under is set at 135.5. Before entering any UCLA vs. Oregon picks, you'll want to see the college basketball predictions from the advanced computer model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of almost $2,600 for $100 players on its top-rated college basketball picks against the spread. It's off to a profitable start in the 2020-21 season, going 12-9 on all its top-rated picks and returning almost $300. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Oregon vs. UCLA. You can head to SportsLine to see its picks. Here are several college basketball odds for Oregon vs. UCLA:

  • Oregon vs. UCLA spread: Oregon -2.5
  • Oregon vs. UCLA over-under: 135.5 points
  • Oregon vs. UCLA money line: Oregon -150, UCLA  +130

What you need to know about Oregon

The Ducks were fully in charge Saturday, breezing past the visiting Portland Pilots 80-41. Oregon's guard Chris Duarte scored 21 points while also recording three blocks and two steals. For the season, Duarte is averaging 15.4 points, 4.9 rebounds and 2.7 assists per game.

Oregon has relied heavily on its seniors so far in 2020. Duarte, Eugene Omoruyi, Eric Williams Jr., LJ Figueroa and N'Faly Dante have combined to account for 78 percent of the team's scoring this year and they've scored 77 percent of Oregon's points over the last five games.

What you need to know about UCLA

The Bruins came up short against the Ohio State Buckeyes on Saturday, falling 77-70. Tyger Campbell has either made or assisted on 40 percent of UCLA's field goals over the last five games, and he's accounted for 17 field goals and 37 assists in those games. However, Campbell struggled mightily in Saturday's loss at Ohio State, finishing with just three points, five assists and one rebound. 

UCLA will enter Wednesday's contest against Oregon confident they can pull off the upset. That's because the Bruins have won four of their last six meetings against Oregon, and they're 4-1 against the spread in their last five games against the Ducks. In addition, UCLA is 8-1 in its last nine games against an opponent from the Pac-12. 

How to make Oregon vs. UCLA picks

The model has simulated Oregon vs. UCLA 10,000 times and the results are in. We can tell you that the model is leaning over, and it's also generated a point-spread pick that is hitting in over 70 percent of simulations. You can only see the pick at SportsLine.

So who wins UCLA vs. Oregon? And which side of the spread cashes in over 70 percent of simulations? Visit SportsLine now to find out which side of the Oregon vs. UCLA spread you need to jump on Wednesday, all from the model that has crushed its college basketball picks, and find out.