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The seventh-ranked Miami (FL) Hurricanes will look to post their first win over a top-ranked opponent in 20 years when they take on the Clemson Tigers on Saturday. Miami has not taken down No. 1 since defeating Florida State on Oct. 7, 2000. The Hurricanes' last win over a No. 1 ranked team on the road was Nov. 16, 1991, at Florida State. In the last 40 seasons, Miami is 9-5 against The top-ranked team in the AP Poll.

The game from Memorial Stadium in Clemson, S.C., is slated to start at 7:30 p.m. ET. Clemson is 15-2 all-time when ranked No. 1 by The Associated Press, and has never lost a regular-season game as the nation's top-ranked team. The Tigers are favored by 15 points in the latest Miami, Fla. vs. Clemson odds from William Hill, while the over-under for total points scored is 59. Before making any Miami vs. Clemson picks, check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $4,200 for $100 players on its top-rated college football picks against the spread. It is a sizzling 20-3 on top-rated picks through five weeks of the 2020 college football season, returning over $1,300 in profit already. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Clemson vs. Miami. You can visit SportsLine now to see the picks. Here are the college football odds from William Hill and trends for Miami vs. Clemson:

  • Clemson vs. Miami spread: Clemson -15
  • Clemson vs. Miami over-under: 59 points
  • Clemson vs. Miami money line: Miami +475, Clemson -650
  • MIA: Has allowed just seven points off turnovers this season
  • CLEM: Has recorded multiple sacks in 25 of its last 26 games, including each of the last nine

Why Clemson can cover

In addition to an elite offense led by Heisman contender Trevor Lawrence, the Clemson defense continues to be menacing and will look to record at least three sacks in a sixth consecutive game dating back to last season. Clemson has 13 on the season and is led by freshman defensive end Myles Murphy, who has two for eight yards. For the year, he is second on the team in tackles with 15, including eight solo. He has also forced one fumble. In his collegiate debut at Wake Forest, he had a team-high seven tackles, including three for loss.

Leading the Tigers in tackles is junior linebacker Baylon Spector with 20, including five solo. He has also recorded one sack. Last week against Virginia, he recorded 13 tackles and earned the Walter Camp National Defensive Player of the Week and ACC Linebacker of the Week honors. Last season, he was credited with 45 tackles, including six for loss, two sacks, one fumble recovery and one pass breakup in 284 snaps in 15 games.

Why Miami can cover

The Hurricanes have one of the nation's top tight end tandems in juniors Brevin Jordan and Will Mallory, who are listed as co-starters on the offensive depth chart this season. Jordan, who has started all three games, torched Louisville in Week 2 and finished with seven catches for 120 yards, including a 47-yard touchdown. For the season, he has 15 catches for 212 yards (14.1 average) and three touchdowns. For his career, Jordan has 82 receptions for 994 yards (12.1 average) and nine TDs.

Mallory opened Miami's scoring against Louisville when he hauled in a 17-yard touchdown reception in the opening quarter. It was his fourth career touchdown and he went on to start in Miami's victory over Florida State. Last season, Mallory caught 16 passes for 293 yards (18.3 average) and two touchdowns. He saw action in all 13 games with eight starts.

How to make Clemson vs. Miami picks

SportsLine's model is leaning under on the total. In fact, it says Lawrence will be held to just over 250 yards and two touchdowns, while Miami quarterback D'Eriq King will pass for just over 150 yards and one TD. It has also generated an against-the-spread pick that cashes in almost 60 percent of simulations. You can only get the pick at SportsLine

So who wins Miami vs. Clemson? And which side of the spread hits almost 60 percent of the time? Visit SportsLine now to see which side of the Clemson vs. Miami spread to back, all from the advanced model that is up over $4,200 on its top-rated college football spread picks, and find out.