Both teams are looking to remain unbeaten Saturday when the Wake Forest Demon Deacons host the Vanderbilt Commodores at Allegacy Federal Credit Union Stadium. The Demon Deacons, who went 8-3 last season, kicked off their 2023 college football season with a 37-17 victory against Elon on Aug. 31. The Commodores opened their season on Aug. 26 with a 35-28 home victory against Hawaii. Then Vandy faced Alabama A&M in Nashville last Saturday and came away with a 47-13 victory. The teams met almost exactly one year ago, and Wake Forest -- then ranked 23rd in the nation -- took a 45-25 road victory on Sept. 9, 2022.

Kickoff at Allegacy Federal Credit Union Stadium is set for 11 a.m. ET. The latest Vanderbilt vs. Wake Forest SportsLine consensus odds list the Demon Deacons as 10-point favorites. The over/under for total points scored is 56.5. Before you make any Wake Forest vs. Vanderbilt picks, be sure to check out the college football predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. The proprietary computer model is off to a fast 4-2 start on all-top rated college football picks this season. Since its inception, it has generated a stunning profit of almost $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Vanderbilt vs. Wake Forest and just revealed its picks and predictions. You can visit SportsLine to see the model's CFB picks. Here are several college football odds and trends for Wake Forest vs. Vanderbilt: 

  • Vanderbilt vs. Wake Forest spread: Demon Deacons -10
  • Vanderbilt vs. Wake Forest over/under: 56.5 points
  • Vanderbilt vs. Wake Forest money line: Demon Deacons -422, Commodores +322
  • Vanderbilt: Is 10-4 ATS as a road underdog since 2020.
  • Wake Forest: Is 9-6 ATS as a home favorite since 2020.
  • Vanderbilt vs. Wake Forest picks: See picks at SportsLine 

Why Wake Forest can cover

Wake hasn't played since Aug. 31, so it will have some extra rest and will be playing in front of its fans. The Deacons went 4-1 against the spread in non-conference games last season. Quarterback Mitch Griffis started just one game in 2022, but he threw for 288 yards against VMI to open last season before Sam Hartman returned. Hartman is now the starter at Notre Dame, so Griffis is the undisputed starter. He kicked off this campaign by throwing for 329 yards and three TDs last week against Elon. He has a lot of talent around him in the Wake Forest offense.

Three receivers had at least 70 yards in the opener, with Jahmal Banks getting 108 and one touchdown and Cameron Hite posting 91 and a score. Running back Demond Claiborne averaged 5.4 yards per carry and also added a TD. The Vandy defense had a rough 2022, ranking 123rd in FBS in total yards (461 per game) and 128th in passing yards (292). The Commodores allowed 36 points, while Wake gave up 28. The Deacons went 5-3 ATS at home in 2022, and the defense can make big plays. Jasheen Davis had seven sacks last season. See which team to pick here.

Why Vanderbilt can cover

Vanderbilt looked like a different team in its second season under Clark Lea. The Commodores won five games after winning two over the previous two seasons combined. They were blown out by four top-10 teams but beat Florida and Kentucky, then ranked 24th in the nation, over their final three games. Vanderbilt was 5-9 against the spread in 2022 but was 4-2 ATS on the road. Quarterback AJ Swann, a strong-armed sophomore, has opened the season strong. Swann has 452 passing yards, five touchdowns and one interception in the first two games.

Jayden McGowan and Will Sheppard both have 12 receptions, and Sheppard has scored four touchdowns. The receivers have combined for 252 yards, and London Humphreys has 55 on two receptions. Sedrick Allen and Patrick Smith have a combined 162 rushing yards, with Allen averaging 6.4 per carry and scoring twice. Linebacker CJ Taylor is the lynchpin on a defense that makes big plays. He has two passes defended and a sack to go with 15 tackles, tied for most on the team. Nate Clifton has two sacks, and De'Rickey Wright has two interceptions. See which team to pick here.

How to make Vanderbilt vs. Wake Forest picks

SportsLine's model is leaning Over on the total, projecting that the teams combine for 60 points. The model also shows one side of the spread is hitting well over 50% of the time. You can only see the model's pick at SportsLine

So who wins Vanderbilt vs. Wake Forest, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has notched a profit of almost $2,500 on its top-rated college football spread picks, and find out.