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The Arizona Diamondbacks (19-21) and the Chicago Cubs (15-22) match up on Friday afternoon in the second game of their four-game series. Chicago fell 3-1 to Arizona on Thursday, dropping its second contest in a row. The season series is currently tied 2-2. Humberto Castellanos (0-0, 4.15 ERA) gets the start for Arizona. Kyle Hendricks (2-3, 4.03 ERA) is on the hill for Chicago.

First pitch is set for 2:20 p.m. ET. Caesars Sportsbook lists Chicago as the -135 favorite (risk $135 to win $100) on the money line in the latest Cubs vs. Diamondbacks odds. Arizona is the +115 underdog, while the over-under for total runs is set at 11.5. Before making any Diamondbacks vs. Cubs picks, you need to see the MLB predictions and betting advice from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a profitable start to the 2022 season. It's on a 33-25 roll on top-rated MLB money-line picks through six weeks, returning over $300 for $100 players. Anyone following it has seen some huge returns.

Now, the model has set its sights on Cubs vs. Diamondbacks and just locked in its picks and MLB predictions. You can head to SportsLine now to see the picks. Here are several MLB odds and trends for Diamondbacks vs. Cubs: 

  • Cubs vs. Diamondbacks money line: Chicago -135, Arizona +115
  • Cubs vs. Diamondbacks run line: Chicago -1.5 (+130)
  • Cubs vs. Diamondbacks over-under: 11.5 runs
  • Cubs vs. Diamondbacks tickets: See tickets at StubHub
  • ARI: Under is 4-0 in Diamondbacks' last four vs. National League Central
  • CHC: Cubs are 4-1 in their last five overall
Featured Game | Chicago Cubs vs. Arizona Diamondbacks

Why you should back the Diamondbacks

Center fielder Daulton Varsho has been a consistent source of offense. Varsho also offers position flexibility on the defensive end with the ability to play catcher. The 25-year-old can hit for both power and average while producing runs for Arizona. Varsho is leading the team in batting average (.252), on-base percentage (.324) and hits (33). He also has seven dingers and 17 RBIs.

First baseman Christian Walker has serious power with run-producing abilities. Walker can play solid defense in the corner, owning a good glove. The 31-year-old leads the team in homers (9) and RBIs (18). On May 17, he went 2-for-4 with a solo home run. During the month of May, Walker recorded 17 total hits, including four doubles.

Why you should back the Cubs

Catcher Willson Contreras is a good hitter with nice pitch recognition, and he'll hit second on Friday. Contreras has good awareness of the strike zone with some home run pop in his swing. The two-time All-Star has a batting average of .263 with five home runs and 14 runs driven in. On May 16, he went 2-for-5 with a double and a grand slam. 

He'll help set the table for a middle of the lineup that includes Ian Happ, Frank Schwindel and Alfonso Rivas. Happ leads the Chicago regulars with a .272 average. Chicago has had a decent amount of success with Hendricks on the hill, going 5-3 in his starts and returning backers +319 on the money line this year. 

How to make Diamondbacks vs. Cubs picks

SportsLine's model is leaning under on the total, projecting 10.1 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

Who will win Cubs vs. Diamondbacks? And which team has all the value on the money line? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.