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The Chicago White Sox visit the Kansas City Royals for Game 1 of a doubleheader on Tuesday afternoon to get the MLB schedule underway. The AL Central rivals began a series on Monday, with the White Sox prevailing in extra innings. Chicago is 17-17 to begin the 2022 campaign. Kansas City is 12-21 overall after a loss in the series opener.

Caesars Sportsbook lists Chicago as the -185 money-line favorite (risk $185 to win $100) for this 2:10 p.m. ET first pitch. The total number of runs Vegas thinks will be scored, or the over-under, is eight in the latest White Sox vs. Royals odds. Before making any Royals vs. White Sox picks, you need to see the MLB predictions and betting advice from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a profitable start to the 2022 season. It's on a 33-25 roll on top-rated MLB money-line picks through six weeks, returning over $300 for $100 players. Anyone following it has seen some huge returns.

Now, the model has set its sights on White Sox vs. Royals and just locked in its picks and MLB predictions. You can head to SportsLine now to see the picks. Here are several MLB odds and trends for Royals vs. White Sox: 

  • White Sox vs. Royals money line: White Sox -185, Royals +165
  • White Sox vs. Royals over-under: 8 runs 
  • White Sox vs. Royals run line: White Sox -1.5 (-120)
  • White Sox vs. Royals tickets: See tickets at StubHub
  • CHI: The White Sox are 8-7 in road games
  • KC: The Royals are 6-10 in home games
Featured Game | Kansas City Royals vs. Chicago White Sox

Why you should back the White Sox

Chicago has star power that projects to be on display on Tuesday. 28-year-old shortstop Tim Anderson is a former All-Star and AL batting champion, and he is off to a strong start in 2022. Anderson is hitting .339 this season, posting a .500 slugging percentage with four home runs and five stolen bases. Anderson helps the White Sox to an outstanding 19.8 percent strikeout rate as a team, and Chicago can lean on impressive run prevention in this matchup. 26-year-old right-hander Dylan Cease has a 3.55 ERA in seven starts this season, striking out 58 batters against only 15 walks. 

He led the American League in strikeout rate in 2022, and Cease has a 2.96 ERA in his career against the Royals. Kansas City's offense is near the bottom of the American league with a .222 batting average and a .287 on-base percentage this season, and the Royals have only 21 home runs. That leads to an ugly .332 slugging percentage, and Kansas CIty has only 121 runs scored in 2022.

Why you should back the Royals

The Royals, who will start righty Jon Heasley (0-1, 2.70 ERA), have a 19.8 percent strikeout rate on offense this season, ranking solidly in the top three of the American League. Kansas City is also prolific in creating triples (eight) and Chicago's offense is off to a less than outstanding start in 2022. The Royals have the benefit of home-field advantage, and the White Sox have only 122 runs scored in 2022. 

Chicago has only 32 home runs and 47 doubles, ranking below the AL average in both power categories. The White Sox are also last in the American League in walk rate, generating a free pass on only 6.1 percent of possessions. That leads to a dismal .283 on-base percentage, and Kansas City can benefit from Chicago's lack of offensive patience.

How to make Royals vs. White Sox picks

SportsLine's model is leaning over on the run total, projecting 9.1 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins White Sox vs. Royals? And which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.