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The Philadelphia 76ers will take on the Minnesota Timberwolves at 8 p.m. ET on Friday at the Target Center. Minnesota is 32-28 overall and 18-11 at home, while the 76ers are 35-23 overall and 19-10 on the road. Philadelphia has won eight of the last nine meetings between these teams. 

Philadelphia is favored by 2.5 points in the latest Timberwolves vs. 76ers odds from Caesars Sportsbook, while the over-under is set at 228.5. Before entering any 76ers vs. Timberwolves picks, you'll want to see the NBA predictions from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past three-plus seasons. The model enters Week 18 of the 2021-22 NBA season on a stunning 69-41 roll on all top-rated NBA picks, returning almost $2,300. Anyone following it has seen huge returns.

Now, the model has set its sights on Timberwolves vs. 76ers. You can head to SportsLine to see its picks. Here are several NBA betting lines for Timberwolves vs. 76ers:

  • Timberwolves vs. 76ers spread: Timberwolves +2.5
  • Timberwolves vs. 76ers over-under: 228.5 points
Featured Game | Minnesota Timberwolves vs. Philadelphia 76ers

What you need to know about the Timberwolves

Minnesota returned from the All-Star break on Thursday night, picking up an impressive 119-114 win over Memphis. The Timberwolves will be wrapping up a four-game homestand on Friday after winning two of their first three games. D'Angelo Russell poured in 37 points in Thursday's win over the Grizzlies, while Karl-Anthony Towns added a double-double with 22 points and 11 rebounds. 

Towns became the second-tallest player to ever win the NBA 3-point contest over the weekend. He has been Minnesota's best player this season, averaging 24.4 points, 9.7 rebounds and 4.0 assists. The Timberwolves have won eight of their last nine home games. 

What you need to know about the 76ers

A new era is expected to begin for Philadelphia on Friday night. The 76ers traded Ben Simmons for James Harden at the trade deadline, but Harden has been held out since then with a hamstring injury. Philadelphia went 3-1 in the four games without him and is expected to have the All-Star guard on the court for this contest. 

Joel Embiid leads the 76ers with 29.6 points, 11.2 rebounds and 4.5 assists per game. Power forward Tobias Harris is adding 18.7 points and 7.3 rebounds, while Tyrese Maxey is scoring 16.9 points. Philadelphia has covered the spread in 11 of its last 14 games against Minnesota. 

How to make 76ers vs. Timberwolves picks

The model has simulated Timberwolves vs. 76ers 10,000 times and the results are in. We can tell you that the model is leaning under, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins 76ers vs. Timberwolves? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to find out, all from the model that has crushed its NBA picks.