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The Boston Celtics will take on the Cleveland Cavaliers at 8 p.m. ET on Saturday at Rocket Mortgage FieldHouse. Cleveland is 8-5 overall and 3-2 at home, while the Celtics are 6-6 overall and 4-3 on the road. The Cavs have been one of the surprises of the NBA so far this season, while the Celtics have been keeping their heads above water with Jaylen Brown (hamstring) out and Jayson Tatum struggling from the floor in the early portion of the season.

The Cavs ended an eight-game winning streak against the Celtics last season by taking two of three in the season series and covering the spread in two of those games as well. But with Cleveland dealing with injury issues, Boston is favored by 2.5 points in the latest Cavaliers vs. Celtics odds from Caesars Sportsbook, and the over-under is set at 202. Before entering any Celtics vs. Cavaliers picks, you'll want to see the NBA predictions from the model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned over $9,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model enters Week 4 of the 2021-22 NBA season up over $500 on all top-rated NBA picks this season. It's also on a stunning 110-73 roll on top-rated NBA picks against the spread that dates back to last season. Anyone following it has seen huge returns.

Now, the model has set its sights on Cavaliers vs. Celtics. You can head to SportsLine to see its picks. Here are several NBA betting lines for Celtics vs. Cavs:

  • Cavaliers vs. Celtics spread: Celtics -2.5
  • Cavaliers vs. Celtics over-under: 202 points
Featured Game | Cleveland Cavaliers vs. Boston Celtics

What you need to know about the Cavaliers

Cleveland made easy work of the Detroit Pistons on Friday and carried off a 98-78 win. Among those leading the charge for the Cavs was point guard Darius Garland, who had 21 points and seven assists. The Cavaliers have had incredibly balanced scoring all year and Garland is leading the team despite averaging just 16.3 points per game.

J.B. Bickerstaff's squad has been one of the best defensive units in the NBA this season, ranking third in the NBA in points per game allowed (102.2) and eighth in defensive rating (105.1). They rank 26th in the NBA in pace, so they'll try to grind the game to halt and the Celtics are 27th in pace, so the value of defensive stop will be high with fewer possessions likely on Saturday.

What you need to know about the Celtics

Meanwhile, it may have taken overtime to finish the job, but Boston ultimately got the result it was hoping for on Friday with a 122-113 victory over the Milwaukee Bucks. Point guard Dennis Schroder was the offensive standout of the matchup for Boston, picking up 38 points along with eight boards.

Schroder is averaging 26.0 points per game over his last three contests and Tatum has also started to find his rhythm. He's averaging 27.0 points and 11.0 rebounds per game in the last three games and the Celtics will be looking to ride that duo to their first three-game winning streak of the season after beating the Raptors and Bucks already this week.

How to make Celtics vs. Cavaliers picks

The model is leaning over on the total and it's also generated a point-spread pick that is hitting in well over 60 percent of simulations. You can only see the pick at SportsLine.

Who wins Celtics vs. Cavaliers? And which side of the spread hits well over 60 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NBA picks.