In Week 7, the Arizona Cardinals (2-4) will host the New Orleans Saints (2-4) in a primetime fight on Thursday Night Football. This contest will be a competitive bout since these NFC teams both badly need a win. Arizona owns a stout run defense, ranking seventh in the league in rushing yards allowed (103.8). New Orleans' offense has had success and is ranked sixth in the NFL in total offense (382.3). Cardinals running back James Conner is inactive with a rib injury.

Kickoff is set for 8:15 p.m. ET from State Farm Stadium. Arizona is favored by 2.5 points in the latest Saints vs. Cardinals odds from Caesars Sportsbook, and the over/under is 43.5. Before making any Cardinals vs. Saints picks, you need to see the NFL predictions and betting advice from the computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 7 of the 2022 NFL season on an incredible 146-107 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Saints vs. Cardinals and just locked in its picks and TNF predictions. You can visit SportsLine now to see the model's picks. Here are the NFL odds and betting lines for Cardinals vs. Saints:

  • Saints vs. Cardinals spread: Arizona -2.5
  • Saints vs. Cardinals over/under: 43.5 points
  • Saints vs. Cardinals money line: New Orleans +122, Arizona -145
  • NO: Saints are 4-1 ATS in their last five games following a straight-up loss
  • ARI: Under is 5-0 in the Cardinals' last five games
  • Saints vs. Cardinals picks: See picks here
Featured Game | Arizona Cardinals vs. New Orleans Saints

Why the Cardinals can cover

Arizona has been able to stuff the run and clog holes up front. The Cardinals are currently seventh in the NFL in rushing yards allowed (103.8). Defensive end Zach Allen is playing well to kick off the campaign. Allen gives maximum effort on each play with the strength and explosiveness to shed blocks. The Boston College product has 25 total tackles, four TFLs, five pass deflections, and two sacks.

Defensive end J.J. Watt is an all-around impact player. Watt has great play recognition skills with the awareness to get his hands up at the line of scrimmage. The five-time Pro Bowler can still quickly get off the line and cause havoc in the backfield. Watt is first on the team in sacks (2.5) with four TFLs and three pass deflections. See which team to back here.

Why the Saints can cover

New Orleans trots out an athletic and attacking linebacker duo. Linebacker Pete Werner is a versatile playmaker who has outstanding game speed and the awareness to quickly dissect the play. Werner has fluid movement in open space with the ability to defend tight ends and running backs. The Ohio State product is tied for first in total tackles (42) and tied for fourth in forced fumbles (2).

Demario Davis is a hard-hitting thumper for this unit. Davis is well-rounded, flying through rush lanes and the nimbleness to be solid in coverage. The two-time Second-Team All-Pro selection can be very effective as a blitzer. Davis is second on the team in total tackles (36) and TFLs (4) but first in sacks (4). In his last game, the Arkansas State product registered nine total tackles and two sacks. See which team to back here.

How to make Saints vs. Cardinals picks

SportsLine's model is leaning Over the total, calling for 48 combined points. It also says one side of the spread has all the value. You can only get the model's TNF picks at SportsLine.

So who wins Cardinals vs. Saints on Thursday Night Football? And which side of the spread has all the value? Visit SportsLine now to see which side of the Cardinals vs. Saints spread to jump on, all from the advanced model that is up almost $7,000 on its NFL picks since 2017, and find out.