The Duke Blue Devils will look to continue their mastery of the Notre Dame Fighting Irish when they meet in Atlantic Coast Conference action on Tuesday. The Blue Devils (17-8, 8-6 ACC), who won last year's meeting 57-43, have won eight of the last nine meetings between the teams. The Fighting Irish (10-15, 2-12), who have lost three straight, last beat Duke 93-89 in 2021. The Blue Devils are coming off a controversial 69-62 overtime loss at Virginia on Saturday, while Notre Dame dropped a 93-87 decision to Virginia Tech. Leading scorer Kyle Filipowski (ankle) is questionable for Duke. 

The game from Cameron Indoor Stadium in Durham, N.C., will tip off at 7 p.m. ET. Notre Dame is averaging 71 points per game, while Duke averages 71.5. The Blue Devils are 12-point favorites in the latest Notre Dame vs. Duke odds from Caesars Sportsbook, while the over/under for total points scored is set at 141. Before making any Duke vs. Notre Dame picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. The model enters Week 15 of the season 66-38 on all-top rated college basketball picks, returning almost $1,700 for $100 players. Anybody who has followed it has seen huge returns. 

Now, the model has set its sights on Duke vs. Notre Dame and just locked in its picks and CBB predictions. You can head to SportsLine now to see the model's picks. Here are several college basketball odds and betting lines for Notre Dame vs. Duke:

  • Duke vs. Notre Dame spread: Duke -12
  • Duke vs. Notre Dame over/under: 141 points
  • Duke vs. Notre Dame money line: Duke -800, Notre Dame +550
  • ND: The Fighting Irish are 9-3 ATS in their last 12 road games against a team with a home winning % of greater than .600
  • DUKE: The Blue Devils are 8-3 ATS in their last 11 games against a team with a losing straight-up record
  • Duke vs. Notre Dame picks: See picks at SportsLine
Featured Game | Duke Blue Devils vs. Notre Dame Fighting Irish

Why Duke can cover

Freshman guard Tyrese Proctor has reached double-digit scoring in three of the past four games, including a 14-point performance on Saturday. Proctor has scored 10 points or more 11 times this year, including a season-high 17 points twice -- at Clemson on Jan. 14 and against Wake Forest on Jan. 31. Proctor is averaging 8.9 points, 3.2 rebounds and 2.8 assists per game. He is one of the team's top free-throw shooters, connecting on 86.7% of his foul shots.

Freshman forward Mark Mitchell is averaging 8.6 points, 4.4 rebounds and 1.2 assists per game. He is known for his defense as opposing players are shooting 33% on field goals and 31.9% on 3-pointers when primarily defended by Mitchell. He is also averaging 6.6 rebounds over the last five games, and 5.1 rebounds in ACC play. He made a game-saving chase-down block in the closing seconds at Boston College on Jan. 7, and finished with 14 points and six rebounds.

Why Notre Dame can cover

Forward Nate Laszewski is coming off a monster game in Saturday's loss to Virginia Tech. He scored 33 points, grabbed eight rebounds and added one block and one steal. The fifth-year senior has started all 25 games he has played and is averaging 14.9 points, seven rebounds and 1.5 assists per game. He is connecting on 54.1% of his field goals, including 42.7% from 3-point range, and 86.2% of his free throws.

Senior guard Cormac Ryan has also been red hot of late, scoring in double digits in each of the last six games, including 19 points at North Carolina State in an 85-82 loss on Jan. 24. He scored 17 points and dished out three assists in Saturday's game. He has scored 10 or more points 16 times, including 20 or more twice. He scored a season-high 23 points in a 70-52 win over Michigan State on Nov. 30. For the season, he is averaging 11.8 points, 4.1 rebounds, 2.6 assists and 1.1 steals.

How to make Notre Dame vs. Duke picks

SportsLine's model is leaning Over on the total, projecting 144 combined points. The model also says one side of the spread hits in well over 50% of simulations. You can only see the model's picks at SportsLine.

So who wins Duke vs. Notre Dame? And which side of the spread hits in well over 50% of simulations? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its college basketball picks, and find out.