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Wednesday's only matchup between two top-25 teams also has big implications in the Big 12 when No. 11 Iowa State hosts No. 25 Texas Tech at 9 p.m. ET. The Cyclones are 12-1 overall and 9-1 at home, while Texas Tech's only two losses of the season have come away from Lubbock -- one of which was a neutral site matchup against No. 4 Gonzaga on December 18. Texas Tech has won the last five meetings between the two programs, but Iowa State holds the overall advantage in the all-time rivalry, 20-19.

The Cyclones are favored by four points in the latest Iowa State vs. Texas Tech odds from Caesars Sportsbook, and the over-under is set at 127. Before entering any Texas Tech vs. Iowa State picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Iowa State vs. Texas Tech. You can head to SportsLine to see its picks. Here are several college basketball odds for Texas Tech vs. Iowa State:

  • Iowa State vs. Texas Tech spread: Iowa State -4
  • Iowa State vs. Texas Tech over-under: 127 points
Featured Game | Iowa State Cyclones vs. Texas Tech Red Raiders

What you need to know about Iowa State

Iowa State was within striking distance but couldn't close the gap this past Saturday in a 77-72 loss to the Baylor Bears. A silver lining for Iowa State was the play of guard Tristan Enaruna, who had 23 points along with eight rebounds. The junior swingman has picked up his play in a big way over Iowa State's last two games, and in the preceding game against Chicago State, he had 19 points and 10 rebounds. Otherwise, Izaiah Brockington has been the top player for the Cyclones this season, and he's averaged 17 points and 8.4 rebounds per game.

Iowa State has been an elite defensive side this season, and averages 9.8 steals per game. Starting guards Gabe Kalscheur and Tyrese Hunter lead the team in that category and both average two steals per game. Additionally, Cyclones opponents have hit just 38 percent of their shots, and score just 57.7 points per contest.

What you need to know about Texas Tech

Texas Tech ended 2021 with a bang, and thrashed the Alabama State Hornets 75-53 last week. The top scorer for Texas Tech was guard Davion Warren (15 points). Warren and fellow senior Bryson Williams make up two-thirds of the team's top scorers this season and both average 11.3 points per game. Those two will need to step up against a top opponent without Terrence Shannon Jr., who is due to miss the game as he continues to recover from a back injury.

Shannon started the season as the team's top producer on offense, but without him in the lineup, Kevin McCullar has emerged as the next top scorer. He has averaged 13.5 points and 6.1 rebounds per game, and has also been the Red Raiders' top player on the glass. Tech has also been a stout defensive team and has averaged 5.1 steals per game while holding opponents to just 37.6 percent shooting and 58.2 points per game.

How to make Iowa State vs. Texas Tech picks

The model has simulated Texas Tech vs. Iowa State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 70 percent of simulations. You can only see the pick at SportsLine.

Who wins Iowa State vs. Texas Tech? And which side of the spread is a must-back? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks and find out.