The Louisville Cardinals will take on the Western Kentucky Hilltoppers at 3 p.m. ET on Saturday at E.A. Diddle Arena
in Bowling Green, Ky., and the game will be broadcast live on CBS. Louisville is 7-3 on the season, while Western Kentucky is 7-4. The in-state rivals are separated by less than a two-hour drive and have played the last two seasons, with Louisville winning both matchups and taking nine in a row in the series.

However, the Hilltoppers should be riding high coming off a dominant blowout win over Ole Miss last Saturday. Still, the Cardinals are favored by 2.5 points in the latest Louisville vs. Western Kentucky odds from Caesars Sportsbook, and the over-under is set at 139.5. Before you make any Western Kentucky vs. Louisville picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,400 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on WKU vs. Louisville. You can head to SportsLine to see its picks. Here are several college basketball odds for Louisville vs. WKU:

  • Louisville vs. Western Kentucky spread: Louisville -2.5
  • Louisville vs. Western Kentucky over-under: 139.5 points
Featured Game | Western Kentucky Hilltoppers vs. Louisville Cardinals

What you need to know about Louisville

Louisville rebounded from a loss to DePaul last Friday by beating Southeastern Louisiana 86-60 on Tuesday. Malik Williams had a double-double in the win with 15 points and 10 rebounds in just 17 minutes of action. He was one of four Cardinals players to score in double-figures and Louisville shot 51.7 percent from the floor.

However, shooting the ball has generally been an issue for Chris Mack's squad, as the Cardinals shot just 31.1 percent in the loss to DePaul and are shooting just 41.8 percent from the floor for the season. Williams is a fifth-year center who is shooting 52.5 percent and leads the team in scoring (10.9 ppg) and rebounding (9.6 rpg), so expect Louisville to make a concerted effort to get the ball inside for high-quality scoring looks.

What you need to know about Western Kentucky

The Hilltoppers got a 71-48 win over Ole Miss last Friday and then followed that up with a 90-52 win over Division III Centre College on Tuesday. In the win over Ole Miss, 7-foot-5 center Jamarion Sharp had 16 points, nine rebounds and six blocked shots and his interior presence could be a problem for the Cardinals.

Dayvion McKnight also had a strong day where he did a little of everything in the win over Ole Miss, contributing eight points, eight rebounds, 11 assists and four steals. McKnight is a do-everything guard who is averaging 14.2 points, 6.7 rebounds, 6.2 assists and 2.3 steals per game and he's another huge reason why Rick Stansbury's squad looks so formidable in 2021-22.

How to make Western Kentucky vs. Louisville picks

The model is leaning under on the total and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Louisville vs. Western Kentucky? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to find out, all from the red-hot model that has crushed its college basketball picks.