The Penn State Nittany Lions will look to win their second consecutive game over the Michigan State Spartans for the first time in program history when they meet in Big Ten Conference action on Wednesday night. The Nittany Lions (6-2, 0-0), who will open up their conference slate, are also looking to improve to 5-0 on their home court this season. The Spartans (5-4, 0-1), who will be playing their first conference road game of the year, are 16-5 in games played at Penn State, although the Lions won last year's meeting 62-58. Michigan State has won 42 of the 52 meetings with Penn State. Michigan State is averaging 70.2 points per game, while Penn State averages 76.9.

The game from Bryce Jordan Center in University Park, Pa., tips off at 6:30 p.m. ET. The Nittany Lions are 4-point favorites in the latest Michigan State vs. Penn State odds from Caesars Sportsbook, while the over/under for total points scored is set at 136.5. Before making any Penn State vs. Michigan State picks, be sure to check out the college basketball predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past six-plus years, the proprietary computer model has generated more than $1,400 for $100 players on its top-rated college basketball picks against the spread. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Michigan State vs. Penn State and just locked in its picks and CBB predictions. You can visit SportsLine now to see the model's picks. Here are the college basketball odds and betting lines for Michigan State vs. Penn State:

  • Michigan State vs. Penn State spread: Penn State -4 
  • Michigan State vs. Penn State over/under: 136.5 points 
  • MSU: The Spartans are 4-1 against the spread in their last five games following a straight-up loss 
  • PSU: The Nittany Lions are 13-2-1 ATS in their last 16 home games 
  • Michigan State vs. Penn State picks: See picks here
Featured Game | Penn State Nittany Lions vs. Michigan State Spartans

Why Penn State can cover

Senior guard Camren Wynter is coming off a 26-point performance in the double-overtime loss to Clemson on Nov. 29. He has reached double figures in each of the past two games, and in four games overall. He scored 18 points in a 90-65 win over Loyola Maryland on Nov. 10. For the season, Wynter is averaging 11.6 points, 2.9 rebounds and 2.1 assists per game.

Also averaging in double figures for Penn State is senior guard Andrew Funk. Funk is averaging 11 points, 2.4 rebounds and 1.6 assists per game. He is coming off a 14-point performance in the loss at Clemson, and has reached double figures in four games. He had a season-high 22 points and four assists in a 93-68 season-opening win over Winthrop on Nov. 7.

Why Michigan State can cover 

The Spartans have been led by senior guard Tyson Walker. In nine starts this season, Walker is averaging 14.4 points, four assists, three rebounds and 1.3 steals per game. He is connecting on 44.3% of his field goals, including 38.2% from 3-point range, and 83.3% from the free throw line. He has reached double figures in seven of nine games, including a 22-point performance in a 73-71 win over Villanova at Gavitt Tipoff Games on Nov. 18.

Senior forward Joey Hauser has also reached double digits in seven of nine games, including a season-high 23 points in an 86-77 double-overtime victory over Kentucky at the State Farm Champions Classic on Nov. 15. He has also recorded a pair of double-doubles, including an 18-point, 10-rebound effort in a 74-70 win over Oregon at the Phil Knight Invitational on Nov. 25. He also had 18 points and 10 boards in a 73-55 season-opening win over Northern Arizona on Nov. 7. For the season, he is averaging 13.2 points, 6.8 rebounds and 1.8 assists per game.

How to make Michigan State vs. Penn State picks

SportsLine's model is leaning Over on the point total, projecting 140 combined points. It has also generated an against-the-spread pick that hits in 70% of simulations. You can only get the model's pick at SportsLine

So who wins Michigan State vs. Penn State? And which side of the spread hits in 70% of simulations? Visit SportsLine now to see which side of the Michigan State vs. Penn State spread to jump on, all from the advanced model that is up more than $1,400 on its college basketball picks the last six years, and find out.