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The Iowa State Cyclones have not fared well in their all-time series against the Oklahoma Sooners, losing 77 of their 86 meetings and tying twice while recording only seven victories. Iowa State has put up a good fight of late, however, going 2-3 in the last five matchups -- with four of the contests being one-score decisions. The Cyclones (6-4, 4-3) attempt to notch their second win in three meetings when they visit the 13th-ranked Sooners (9-1, 6-1) for a Big 12 showdown on Saturday. Both teams are coming off defeats, as Iowa State dropped a 41-38 decision at Texas Tech last week while Oklahoma had its 17-game winning streak halted with a 27-14 loss at Baylor.

Kickoff at Memorial Stadium in Norman, Okla. is set for noon ET. The Sooners are 3.5-point favorites in the latest Oklahoma vs. Iowa State odds from Caesars Sportsbook, while the over-under for total points scored is 59. Before locking in any Iowa State vs. Oklahoma picks and college football predictions, you need to see what the SportsLine Projection Model has to say.

The model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 12 of the 2021 season on a 36-23 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Oklahoma vs. Iowa State and just locked in its CFB picks and predictions. You can visit SportsLine now to see the model's picks. Here are the college football odds and betting lines for Iowa State vs. Oklahoma:

  • Oklahoma vs. Iowa State spread: Sooners -3.5
  • Oklahoma vs. Iowa State over-under: 59 points 
  • Oklahoma vs. Iowa State money line: Sooners -170, Cyclones +145 
  • OKLA: The Sooners are 5-0 against the spread in their last five home games against teams with winning records 
  • ISU: The Cyclones are 5-1 ATS in their last six meetings with the Sooners
Featured Game | Oklahoma Sooners vs. Iowa State Cyclones

Why Oklahoma can cover

Losing back-to-back regular-season games is a rare occurrence for the Sooners as they are 41-1 following a setback since 1999, when they were defeated 38-28 by Texas after falling 34-30 at Notre Dame a week earlier. Oklahoma looks to put last week's 27-14 loss at Baylor in the rearview mirror and get back in the win column behind its offense. The Sooners scored 35 or more points in five straight contests prior to the loss to the Bears, producing at least 52 three times in that span, and lead the Big 12 while ranking 17th in the nation with an average of 455.3 yards per game.

Freshman quarterback Caleb Williams has completed 82-of-117 pass attempts for 1,233 yards with 14 touchdowns and three interceptions in his last five games while also rushing for 244 yards and four scores, including three of 40 or more yards. In that same span, Kennedy Brooks has averaged 107.8 rushing yards while running for six TDs. The redshirt junior, who sat out the 2020 season due to coronavirus concerns, has found the end zone in 11 of his last 13 games dating back to 2019 and needs 143 yards to join De'Mond Parker (1996-98), Adrian Peterson (2004-06) and Samaje Perine (2014-16) as the only Sooners to record three 1,000-yard seasons.

Why Iowa State can cover

Breece Hall was limited to a season-low 51 yards on 18 carries last week but still managed to rush for a pair of touchdowns. The junior also hauled in a scoring pass in the loss, giving him a total of 18 TDs -- one fewer than Marshall's Rasheen Ali for most in the nation. Hall is tied for fourth with 16 rushing scores and ranks sixth in the country in rushing with 1,172 yards.

Hall has been impossible to keep out of the end zone, registering at least one touchdown in each of his last 22 games and 24 of the past 25. After failing to score in the first four contests of his collegiate career, he has recorded 51 TDs -- fifth-most in Big 12 history -- over 30 games. On the other side of the ball, Iowa State ranks 10th in the nation in total defense (306.8 yards) and has allowed more than 350 yards only twice this season.

How to make Oklahoma vs. Iowa State picks

SportsLine's model is leaning over on the total, projecting 63 combined points. It also has generated an against-the-spread pick that cashes in well over 50 percent of simulations. You can only get the model's Iowa State vs. Oklahoma pick at SportsLine.

So who wins Iowa State vs. Oklahoma? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to see which side of the Oklahoma vs. Iowa State spread to back, all from the advanced model that is up almost $3,500 on its top-rated college football spread picks, and find out.