The Los Angeles Angels were -180 favorites in their 5-3 loss to Baltimore on Friday night, as the Orioles jumped out to a 5-0 lead and held on down the stretch. Baltimore will be looking for another big upset on Saturday night. Caesars Sportsbook has Los Angeles priced as a -260 favorite in the latest 2022 MLB odds, while Baltimore is a +220 underdog. Right-handed pitcher Noah Syndergaard is 2-0 with a 1.59 ERA through his first two starts with Los Angeles.

Baltimore's Spenser Watkins allowed one run on two hits against Oakland in his last start. Saturday night's game features a pair of pitchers who are off to strong starts, which is why the over-under is only set at 8.5 runs. What are the MLB best bets in that game and others on Saturday's schedule? Before locking in any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a sizzling start to the 2022 season. It's on a 14-4 roll on top-rated MLB money-line picks through two weeks, returning over $800 for $100 players. Anyone following it has seen huge returns.

Now, the model has locked in four confident MLB best bets for Saturday. They all involve games at 6:10 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of more than 11-1. You can see the model's MLB picks for Saturday only at SportsLine. 

Top MLB picks today

After simulating each of Saturday's games 10,000 times, the model likes Tampa Bay to beat Boston as a -130 favorite at 6:10 p.m. ET. The Rays are led by one of the hottest hitters in the MLB, with Wander Franco batting at a .393 clip through the first two weeks of the season. He hit a pair of home runs in a loss to Boston on Friday night.

Tampa Bay will be using its bullpen on Saturday night, starting with right-hander J.P. Feyereisen, who has thrown 5.1 scoreless innings so far in 2022. He has had success against Boston in the past, going 1-0 with a 1.42 ERA in five career appearances. Boston is without manager Alex Cora due to COVID-19, providing Tampa Bay with another advantage on Saturday night. 

Featured Game | Tampa Bay Rays vs. Boston Red Sox

How to make MLB picks and parlays for Saturday

The model also locked in three other best bets for Saturday, including an over-under that has a ton of value. You can only see the model's MLB parlay picks and best bets for Saturday at SportsLine

What MLB picks should you target for a payout of more than 11-1? And what over-under is the model strongly backing on Saturday? Visit SportsLine now to see the MLB best bets for Saturday from a model that has a 14-4 record on top-rated MLB money-line picks through two weeks, and find out.