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The Detroit Tigers and Cleveland Guardians square off on Wednesday afternoon. Comerica Park hosts the American League Central battle between long-time rivals. The game is also the finale of a four-game set, with the Tigers winning the first three meetings. Cleveland has lost five of six, and the Guardians could fall back to .500 with another loss on Wednesday.

First pitch is at 1:10 p.m. ET in Detroit. Caesars Sportsbook lists Cleveland as a -190 favorite (risk $190 to win $100) on the money line, while the over-under, or total number of runs Vegas thinks will be scored, is eight in its latest Guardians vs. Tigers odds. Before you make any Guardians vs. Tigers picks, you need to see the MLB predictions and betting advice from SportsLine's advanced computer simulation model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is 271-232 on top-rated MLB money-line picks since the start of the 2021 season, returning well over $500 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Guardians vs. Tigers, and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Now, here are several MLB odds and betting lines for Guardians vs. Tigers:

  • Guardians vs. Tigers money line: Guardians -190, Tigers +158
  • Guardians vs. Tigers over-under: 8 runs 
  • Guardians vs. Tigers run line: Guardians -1.5 (-105)
  • CLE: The Guardians are 22-20 in day games 
  • DET: The Tigers are 19-22 in day games
  • Guardians vs. Tigers picks: See picks here.
Featured Game | Detroit Tigers vs. Cleveland Guardians

Why you should back the Guardians

Cleveland is in a rock-solid position with Shane Bieber on the mound. The 2020 AL Cy Young winner is a two-time All-Star, and the 27-year-old right-hander is one of the best in the game. Bieber owns a 2.72 ERA over the last three seasons, striking out almost 12 batters per nine innings over that sample. In 2022, Bieber has a 3.16 ERA, and he is walking only 2.2 batters per nine innings. He is also allowing only 0.7 home runs per nine innings this season, and opponents have a .658 OPS against Bieber. 

Bieber is also pitching quite well lately, posting a 2.62 ERA over the last nine starts, and he owns a 2.51 ERA on the road in 2022. Finally, Detroit is strongly below the AL average in several key offensive metrics, and Bieber maintains a sterling 2.18 ERA in 10 career outings against the Tigers.

Why you should back the Tigers

Detroit has intriguing offensive characteristics, including a top-tier mark in triples and above-average strikeout avoidance. In addition, the Tigers excel in run prevention and their projection is strong for Wednesday. Veteran right-hander Michael Pineda is scheduled to take the ball for the Tigers, and the 33-year-old former All-Star is performing well in 2022. Pineda has a 3.62 ERA and a 1.13 WHIP this season, issuing only 1.3 walks per nine innings. Right-handed hitters are struggling to a .662 OPS against Pineda, and he is pitching well at Comerica Park with a 2.82 ERA in home outings. 

When Pineda exits, he is backed up by a bullpen that ranks in the top five of the American League in ERA and wins above replacement, and Detroit's overall home-field advantage should manifest on Wednesday.

How to make Guardians vs. Tigers picks

SportsLine's model is leaning under on the total, and it says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Guardians vs. Tigers? And which side has all the value? Visit SportsLine now to see which side of Guardians vs. Tigers you need to jump on Wednesday, all from the model that has crushed its MLB picks, and find out.