The Cleveland Guardians (76-65) host the Chicago White Sox (73-70) in a divisional battle on Thursday afternoon. The Guardians head into this game on a six-game win streak. Meanwhile, Chicago has dropped two of its last three games. The Guardians are 5-1 in their last six vs. the American League Central, while the White Sox are 4-0 in their last four games following a loss.

The first pitch is set for 1:10 p.m. ET from Progressive Field. The White Sox are listed at -155 in the money line (risk $155 to win $100) in the latest White Sox vs. Guardians odds from Caesars Sportsbook. The over-under for total runs scored is 7.5. Before making any Guardians vs. White Sox picks, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is a 316-272 on top-rated MLB money-line picks since the start of the 2021 season. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on White Sox vs. Guardians and revealed its coveted picks and predictions. You can head to SportsLine to see all of the model's MLB picks. Here are several MLB odds and trends for Guardians vs. White Sox:

  • White Sox vs. Guardians money line: White Sox -155, Guardians +130
  • White Sox vs. Guardians run-line: Cleveland +1.5 (-130)
  • White Sox vs. Guardians over-under: 7.5 runs
  • CHW: White Sox are 4-0 in their last four during game 1 of a series
  • CLE: Guardians are 6-0 in their last six overall
  • White Sox vs. Guardians: See picks at SportsLine
Featured Game | Cleveland Guardians vs. Chicago White Sox

Why you should back the Guardians

First baseman Josh Naylor is a dependable offensive outlet for the Guardians. Naylor has a stronger lower half that allows him to generate plenty of power and pop in his swing. The 25-year-old offers position flexibility to play either first base or left field. Naylor has belted 17 home runs with 66 RBI.

Shortstop Amed Rosario makes an impact in different ways for Cleveland. Rosario has a great throwing arm with pinpoint accuracy. The 26-year-old can steal bases with the ability to hit for average as he's batting .275 with 55 RBI. On Sept. 12, he was 2-for-4 with two doubles and one run was driven in. 

Why you should back the White Sox

First baseman Jose Abreu is an explosive bat and has all the tools needed to thrive. Abreu owns an electric and powerful swing that drives the ball into any gap. The three-time All-Star displays good patience at the plate as well and is seventh in the league in batting average (.310) with 67 RBI. On Sept. 13, he went 2-for-3 with a solo homer.

Right fielder Andrew Vaughn is an all-around hitter who hits for both power and average with his controlled swing. He is able to consistently produce extra-base hits and home runs. The 24-year-old is batting .289 with 15 home runs and 68 RBI. On Sept. 10, he went 4-for-5 with a double, and two runs were driven in.

How to make White Sox vs. Guardians picks

SportsLine's model is leaning Over on the total, projecting 7.9 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Guardians vs. White Sox? And which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.