The Denver Broncos visit the Seattle Seahawks for a Week 1 tilt on Monday Night Football. The cross-conference matchup will conclude a busy weekend of NFL action, and quarterback Russell Wilson will be in the center of the frame. Wilson was acquired by the Broncos in the offseason and will make his debut with Denver in a familiar place. Wilson was formerly the face of the Seahawks and will now oppose his old team, which is led by head coach Pete Carroll.

Kickoff is at 8:15 p.m. ET in Seattle. Caesars Sportsbook lists Denver as a 6.5-point road favorite, while the over/under, or total number of points Vegas thinks will be scored, is 44 in the latest Broncos vs. Seahawks odds. Before making any Seahawks vs. Broncos picks, be sure to see the NFL predictions and betting advice from SportsLine's proven model.

The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception. The model enters the 2022 NFL season on an incredible 138-97 run on top-rated NFL picks that dates back to the 2017 season. Amazingly, it hasn't missed a top-rated pick since Week 15 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Broncos vs. Seahawks, and just locked in its Monday Night Football picks and predictions. You can head to SportsLine now to see the model's picks. Now, here are several NFL odds and betting lines for Seahawks vs. Broncos:

  • Broncos vs. Seahawks spread: Broncos -7
  • Broncos vs. Seahawks over/under: 44 points
  • Broncos vs. Seahawks money line: Broncos -320, Seahawks +250
  • DEN: Broncos were 8-9 against the spread in 2021
  • SEA: Seahawks were 9-8 against the spread last season
  • Broncos vs. Seahawks picks: See picks at SportsLine
Featured Game | Seattle Seahawks vs. Denver Broncos

Why the Broncos can cover

The Broncos return a strong defense and project to upgrade on offense with Russell Wilson. The newly acquired quarterback is a nine-time Pro Bowl selection and one of only four quarterbacks in NFL history with a career passer rating of more than 100. Wilson is 29-11-1 as a starting quarterback in primetime games, the second-best winning percentage of any signal-caller, and has more than 37,000 career passing yards and more than 4,600 career rushing yards.

In 2021, Wilson was leading the NFL in yards per attempt, touchdown-to-interception ratio, and passer rating before suffering a finger injury and projects to be fully healthy to transform Denver's passing game. On defense, the Broncos were stout across the board, especially in keeping points off the scoreboard. Denver ranked No. 3 in points allowed and No. 5 in points allowed per drive, with top-eight marks in passing yards allowed, total yards allowed, first downs allowed, and rushing yards allowed.

Why the Seahawks can cover

Seattle has a new quarterback involved, with starter Geno Smith on board. The Seahawks should make life easy for their signal-caller, however, as the team has strong skill position talent. Seattle finished No. 3 in the NFL with 5.0 yards per carry last season, and the Seahawks racked up 18 rushing touchdowns. Rashaad Penny is a standout when healthy, and he rushed for more yards (671) than any player in the NFL over the last five weeks of the 2021 season. Penny led the league with 6.3 yards per carry over the full 2021 sample, and the Seahawks also have top-flight receiving talent.

Veteran Tyler Lockett contributed 1,175 receiving yards and eight touchdowns last season. Lockett has a streak of three straight 1,000-yard seasons and has caught at least eight touchdowns in four consecutive campaigns. Lockett is flanked by DK Metcalf, who generated 12 touchdowns last season and is in the top eight of NFL history with 29 receiving touchdowns over his first three seasons. With a defense that stones the running game, allowing only 3.8 yards per carry last season, the Seahawks can force Denver into uncomfortable situations.

How to make Seahawks vs. Broncos picks

SportsLine's model is leaning Under on the total, projecting 41 combined points scored. The model also says one side of the spread hits in well over 50% of simulations. You can only see the model's Broncos vs. Seahawks picks at SportsLine.

So who wins Seahawks vs. Broncos on Monday Night Football? And which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Seahawks vs. Broncos spread you need to jump on, all from the model that's 138-97 on NFL picks, and find out.