The Tennessee Titans will try to avoid starting the season 0-2 for the first time in a decade when they take on the Buffalo Bills on Monday Night Football. Tennessee opened the regular season at home and let a 13-point halftime lead slip away en route to a 21-20 loss to the New York Giants last Sunday. Buffalo, meanwhile, started fast, as the Bills cruised to a 31-10 win over the Rams in Los Angeles. Both teams are looking to repeat their division championships. The Titans are coming off an AFC South title at 12-5, while the Bills won the AFC East with an 11-6 mark.

Kickoff from Highmark Stadium in Orchard Park, N.Y., is set for 7:15 p.m. ET. Buffalo is a 10-point favorite in the latest Titans vs. Bills odds from Caesars Sportsbook, while the over/under for total points scored is 47.5. Before making any Bills vs. Titans picks, be sure to see the NFL predictions and betting advice from SportsLine's Larry Hartstein.

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. Entering the 2022 NFL season, he is 427-344 all-time on NFL sides (plus $3,764 for $100 players), including 394-330 against the spread. Hartstein went 68-50 ATS (58 percent) and 8-3 on money-line plays last season for a profit of $1,552.

In addition, Hartstein has gone 23-12-1 on his last 36 NFL picks involving the Titans, returning $1,007. Anyone who has followed him is way up.

Now, Hartstein has set his sights on Titans vs. Bills and locked in his NFL picks and predictions. You can head to SportsLine to see his picks. Here are several NFL odds and trends for Bills vs. Titans:

  • Titans vs. Bills spread: Buffalo -10
  • Titans vs. Bills over-under: 47.5 points
  • Titans vs. Bills money line: Tennessee +360, Buffalo -480
  • TEN: Titans are 8-2 against the spread in their last 10 Monday games
  • BUF: Bills are 4-0-1 ATS in their last five games as favorites
  • Titans vs. Bills picks: See picks at SportsLine
Featured Game | Buffalo Bills vs. Tennessee Titans

Why the Bills can cover

Quarterback Josh Allen is off to another fast start for Buffalo. Last week in a win over the Rams, Allen completed 26 of 31 passes (83.9 percent) for 297 yards and three touchdowns. He also rushed 10 times for 56 yards and a score. In four-plus seasons as the Bills' QB, Allen has completed 62.6 percent of his passes and has a rating of 91.4. Despite two picks against Los Angeles, Allen compiled a rating of 112 in Week 1.

Defensively, linebacker Von Miller made his presence felt. He had three tackles for loss and two sacks last week in his Buffalo debut. It was his 21st career game with two or more sacks, fourth-most among active players. In four career games against Tennessee, Miller has 2.5 sacks and two forced fumbles. Miller had 9.5 sacks in 2021 while spending time in Denver and with the Los Angeles Rams. He has 117.5 career sacks.

Why the Titans can cover

Quarterback Ryan Tannehill was steady in the loss to the Giants in Week 1. He completed 20 of 33 passes (60.6 percent) for 266 yards and two touchdowns for a rating of 106.4. Tannehill is coming off a season in which he completed 67.2 percent of his passes, completing 357 of 531 attempts for 3,734 yards and 21 touchdowns. He was intercepted 14 times and had a rating of 89.6. The year before he had a rating of 106.5 with 33 touchdowns and seven picks.

Defensively, the Titans are stout. Last week, defensive tackle Jeffery Simmons registered two sacks and his second career forced fumble. It was also his third-ever game with two or more sacks. In Tennessee's last meeting with Buffalo last October, Simmons registered a sack in a 34-31 Titans win. For his career, Simmons has 141 tackles, including 88 solo, with two forced fumbles, three fumble recoveries, 15.5 sacks and 12 pass breakups.

How to make Bills vs. Titans picks

Hartstein has analyzed this matchup from every angle and while we can tell you he's leaning Over the total, he has discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and who to back, at SportsLine.

So who wins Bills vs. Titans on Monday Night Football? And what critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Bills vs. Titans spread to back, all from the NFL expert who's 23-12 on picks involving Tennessee, and find out.