A primetime battle on Monday Night Football features the San Francisco 49ers (1-2) hosting the Los Angeles Rams (2-1). This will be a battle between two offensive masterminds in Kyle Shanahan and Sean McVay. McVay is 4-7 against Shanahan head-to-head, and the 49ers will be without star left tackle Trent Williams (high-ankle sprain). Both teams are 1-2 against the spread this season.

Kickoff from Levi's Stadium in Santa Clara, Calif., is set for 8:15 p.m. ET. San Francisco is favored by two points in the latest Rams vs. 49ers odds from Caesars Sportsbook, and the over/under is 42.5. Before making any 49ers vs. Rams picks, you have to check out the NFL predictions and betting advice from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2022 NFL season on an incredible 139-103 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has broken down Monday's 49ers vs. Rams matchup and just locked in its picks and MNF predictions. You can head to SportsLine now to see the model's picks. Here are the NFL odds and betting lines for Rams vs. Niners:  

  • Rams vs. 49ers spread: San Francisco -2
  • Rams vs. 49ers over/under: 42.5 points
  • Rams vs. 49ers money line: Los Angeles +110, San Francisco -130
  • SF: 49ers are 5-0 ATS in their last five home games
  • LAR: Rams are 4-1 ATS in their last five Monday games
  • Rams vs. 49ers picks: See picks at SportsLine
Featured Game | San Francisco 49ers vs. Los Angeles Rams

Why the 49ers can cover

San Francisco has a dominant and forceful defense. This unit owns an aggressive defensive line that puts pressure and gets after the quarterback. They are currently second in total yards allowed (227). Defensive lineman Nick Bosa is the best player up front for the 49ers. Bosa can win with either speed or power while owning a relentless motor.

The Ohio State product has the speed to get around offensive tackles and gives maximum effort on each play. He's first on the team in sacks (4) and tackles for loss (4) with 11 total tackles. Linebacker Fred Warner is a fast playmaker who runs sideline to sideline. The 2020 Pro-Bowl selection excels in coverage with outstanding instincts. Warner is fourth on the team in total tackles (16) with one pass deflection.

Why the Rams can cover

Los Angeles has plenty of star power on this roster. They have cornerback Jalen Ramsey and defensive lineman Aaron Donald leading the defensive unit. Ramsey is a shutdown corner who is a physical and reliable tackler. The five-time Pro Bowl selection has elite range and length to dispute opposing receivers and quarterbacks. The Florida State product has 16 total tackles, four pass deflections, and one interception.

Donald is a legitimate game wrecker for Los Angeles. The seven-time First-Team All-Pro selection excels at getting past blockers and getting into the backfield. He is extremely powerful and manhandles opposing linemen. Donald has 10 total stops, two sacks, and three tackles for loss. In his last outing, he logged six tackles and a sack.

How to make Rams vs. 49ers picks

The model has broken down Niners vs. Rams on Monday Night Football from all angles. It is leaning Under on the total, projecting 40 combined points. The model also says one side of the spread hits well over 50% of the time. You can only get the model's MNF picks at SportsLine.

So who wins 49ers vs. Rams on Monday Night Football? And which side of the spread hits more than 50% of the time? Visit SportsLine right now to find out which side of the 49ers vs. Rams spread you should be all over Monday, all from the model on a 139-103 roll on its top-rated NFL picks, and find out.