No. 20 Ole Miss (3-1) will try to bounce back from its first loss of the season when it hosts No. 13 LSU (3-1) on Saturday evening. The Rebels came up short in Tuscaloosa, Ala., last week, as Alabama cruised to a 24-10 win. LSU extended its winning streak to three games with a 34-31 win against Arkansas, but it did not cover the spread as a heavy favorite. The Tigers rolled to a 45-20 victory when they faced the Rebels last season. 

Kickoff is set for 6 p.m. ET on Saturday at Vaught-Hemingway Stadium at Hollingsworth Field in Oxford, Miss. The Tigers are favored by 2.5 points in the latest Ole Miss vs. LSU odds, while the over/under is 67 points, per SportsLine consensus. Before entering any LSU vs. Ole Miss picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of nearly $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

The model has set its sights on Ole Miss vs. LSU. You can head to SportsLine to see its picks. Here are several college football odds and betting lines for LSU vs. Ole Miss:

  • Ole Miss vs. LSU spread: Ole Miss +2.5
  • Ole Miss vs. LSU over/under: 67 points
  • Ole Miss vs. LSU money line: Ole Miss: +119, LSU: -141
  • Ole Miss vs. LSU picks: See picks here
  • Ole Miss vs. LSU live stream: fubo (try for free)

Why Ole Miss can cover

Ole Miss has been nearly unstoppable offensively in its two home games this season, scoring a combined 121 points in wins over Mercer and Georgia Tech. The Rebels will be happy to return home following their loss at Alabama, as they have won 16 of their last 18 home games. They have also covered the spread in five of their last seven September games. 

Junior quarterback Jaxson Dart has thrown for 1,096 yards and seven touchdowns while rushing for a team-high 219 yards and three scores. Senior wide receivers Jordan Watkins and Dayton Wade have each gone over 300 receiving yards, while senior wideout Tre Harris has five receiving touchdowns. The Rebels bounced back from a loss to Alabama two years ago, finishing 10-2 with a Sugar Bowl appearance. 

Why LSU can cover

LSU got off to a slow start when it lost to Florida State in Week 1, but it has bounced back with a trio of victories. The Tigers have scored at least 34 points in all three of those games, including their win against Arkansas last week. Quarterback Jayden Daniels threw for 320 yards and four touchdowns in that shootout, while running back Logan Diggs had 97 rushing yards on 14 carries. 

Daniels has been named the SEC Co-Offensive Player of the Week each of the last two weeks, sharing the honor with teammate Malik Nabers two weeks ago. Nabers had 13 receptions for 239 yards and two touchdowns against Mississippi State before adding 130 yards and two more scores against Arkansas. The Tigers have won six of their last seven games against Ole Miss, covering the spread in five of those meetings. See which team to pick here. 

How to make Ole Miss vs. LSU picks

The model has simulated LSU vs. Ole Miss 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that has is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

So who wins Ole Miss vs. LSU, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the LSU vs. Ole Miss spread to jump on, all from the advanced computer model that's up nearly $2,500 on its top-rated college football spread picks since its inception, and find out.