Houston won four of its first five games this season, but it has lost consecutive games since then. The Astros came up well short in a 11-1 final at Seattle on Friday night, as the Mariners scored in six of their eight innings at the plate. They will meet for the second game of their three-game series on Saturday night at 9:10 p.m. ET. Houston is priced as a -150 favorite (risk $150 to win $100) in the latest MLB odds at Caesars Sportsbook.

Elsewhere on the Saturday MLB schedule, the Rockies are -130 favorites against the Cubs at 8:10 p.m. ET. Chicago won the series opener on Thursday, but Colorado bounced back with a 6-5 win on Friday. Before locking in any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

This model, which simulates every game 10,000 times, enters Week 2 of the 2022 season on a 216-181 roll on top-rated MLB money-line picks that dates back to last season, returning over $900 for $100 players. Anyone following it has seen huge returns.

Now, the model has locked in four confident MLB best bets for Saturday night. They all involve games after 7:10 p.m. ET, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of more than 12-1. You can see the model's MLB picks for Saturday only at SportsLine. 

Top MLB picks today

After simulating each of Saturday's games 10,000 times, the model likes Houston and Seattle to go over 7.5 runs (+100) in the Mariners vs. Astros matchup. Seattle's offense was firing on all cylinders on Friday, scoring 11 runs on 13 hits against Houston. Second baseman Adam Frazier had one of the best games of his career, going 4-for-5 at the plate.

Houston is off to a slow start offensively, but the Astros are bound to turn things around soon. They still have one of the most talented lineups in the MLB, led by players like Jose Altuve, Michael Brantley and Alex Bregman. SportsLine's model has this game going over the total in more than 60 percent of simulations, providing value as a parlay leg on Saturday. 

Featured Game | Seattle Mariners vs. Houston Astros

How to make MLB picks and parlays for Saturday

The model also locked in three other best bets for Saturday, including a home underdog that has a ton of value. You can only see the model's MLB parlay picks and best bets for Saturday at SportsLine

What MLB picks should you target for a payout of more than 12-1? And what home underdog is the model strongly backing on Saturday? Visit SportsLine now to see the MLB best bets for Saturday from a model that has a 216-181 record on top-rated MLB money-line picks dating back to 2021, and find out.