The Seattle Mariners and Toronto Blue Jays began their 2022 MLB playoffs on Friday afternoon. The American League foes square off in Game 1 of a best-of-three Wild Card Series in Canada. Seattle is the No. 5 seed after a 90-win season that broke the team's two-decade postseason drought. Toronto is the No. 4 seed with 92 victories in 2022. A pair of All-Star pitchers will be on the mound in Luis Castillo (8-6, 2.99) for Seattle and Alek Manoah (16-7, 2.24) for Toronto.

Caesars Sportsbook lists the Blue Jays as -130 money line favorites, and first pitch is scheduled for 4:07 p.m. ET. The total number of runs Vegas thinks will be scored, or the over/under, is 7 in the latest Blue Jays vs. Mariners odds. Before you make any MLB picks with the Mariners vs. Blue Jays match-up, you need to see the MLB predictions and betting advice from SportsLine's advanced computer simulation model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it entered the final week of the regular season on an 18-8 run on top-rated money-line MLB picks, returning almost $700 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen huge returns.

Now, the model has set its sights on Mariners vs. Blue Jays and just locked in its picks and MLB playoff predictions. You can head to SportsLine now to see the model's picks. Now, here are several MLB odds and betting lines for Blue Jays vs. Mariners:

  • Mariners vs. Blue Jays money line: Blue Jays -130, Mariners +110
  • Mariners vs. Blue Jays over/under: 7 runs 
  • Mariners vs. Blue Jays run line: Blue Jays -1.5 (+170)
  • SEA: The Mariners are 44-37 in road games 
  • TOR: The Blue Jays are 47-34 in home games 
  • Mariners vs. Blue Jays picks: See picks here
Featured Game | Toronto Blue Jays vs. Seattle Mariners

Why you should back the Mariners

Seattle will deploy a tremendous starting pitcher in Castillo as the two-time All-Star has 4.53 strikeouts for every walk since being traded to the Mariners midseason. Opponents have a .611 OPS against Castillo this season, and he has a 52.7% ground ball rate for his career. When Castillo leaves the game, Seattle's bullpen is also stout, posting a 3.33 ERA with 9.65 strikeouts and only 2.99 walks per nine innings.

On the offensive end, Seattle is incredibly patient, ranking No. 2 in the American League with 596 walks this season. The Mariners are also in the top five with 197 home runs and rank above the American League average in stolen bases, OPS, and triples for the 2022 campaign.

Why you should back the Blue Jays

While Seattle is also sending a quality starting pitcher to the mound, Toronto can match that offering with Manoah. He was a first-time All-Star in 2022, producing a 2.22 ERA in 196.2 innings this season. He also has a 0.99 WHIP and only 2.3 walks per nine innings, with opponents posting a .582 OPS against him. Manoah has a 2.45 career ERA against Seattle, and he has 97 strikeouts versus only 11 walks against right-handed batters in 2022.

Seattle was in the bottom five of the American League in hits, doubles, strikeouts and batting average, and Toronto's offense is outstanding. The Blue Jays finished No. 2 in the American League in runs scored, with top-three marks in hits, batting-average, home runs, OPS and total bases. Five players have at least 24 home runs for the Blue Jays, and there are no easy outs in Toronto's lineup.

How to make Mariners vs. Blue Jays picks

SportsLine's model is leaning Over on the run total, projecting 7.6 combined runs, and it says one side of the money line has all the value. You can only get the model's MLB postseason picks at SportsLine.

So who wins Blue Jays vs. Mariners? And which side has all the value? Visit SportsLine now to see which side of Mariners vs. Blue Jays you need to jump on Friday, all from the model that has crushed its MLB picks, and find out.