That includes the Mariners' next opponent -- the defending World Series champion Boston Red Sox.
Here's everything you need to know about the American League foes' showdown Thursday:
MLB Opening Day viewing information
- Date: Thursday, March 28
- Time: 7:10 p.m. ET
- Location: T-Mobile Park -- Seattle, Washington
- TV: ESPN
- Live Stats: GameTracker
- Picks: Check SportsLine's MLB pick sheet for all your daily odds
- Odds: Red Sox -195 / Mariners +165
Red Sox: Boston's title defense begins Thursday, and the only significant piece missing from their Opening Day lineup will be World Series MVP Steve Pearce, who's injured. Closer Craig Kimbrel was a big offseason loss out of the bullpen (even though he remains unsigned), but otherwise, there's little reason to believe the Sox won't be among MLB's top title contenders again. Their relievers aren't as lethal as those of the rival New York Yankees, but their star power -- from Mookie Betts to J.D. Martinez to Opening Day ace Chris Sale -- is enough to scare the rest of the league.
Mariners: After falling out of a once-promising playoff race in 2018, Seattle completely remade itself over the winter, parting ways with just about every recognizable talent in the name of prospect acquisition. Pay little mind to their 2-0 record after the Japan series. They may have some fight in them, especially if Tim Beckham keeps it up and their veteran plug-ins can get hot, but overall, they can't be expected to sniff the postseason this time around.
Marco Gonzales looked promising in Seattle's actual opener, and he's still fresh from that outing. But this is the Red Sox we're talking about. Sale's numbers vs. the Mariners lean heavily in his favor, and with Boston's lineup, this is a pretty easy decision.
Pick: Red Sox -195