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The Cleveland Indians will look for the split of the season series when they meet the Cincinnati Reds in interleague action on Monday. It will be a makeup of a rainout from May 9. The Reds (61-51), who are coming off a four-game sweep of the Pittsburgh Pirates, have won five in a row. The Indians (54-55), who are 28-24 in home games this year, are 12-5 in their last 17 games against Cincinnati. Luis Castillo (6-10, 4.09 ERA) will take the hill for Cincinnati and he'll be opposed by Cleveland's Sam Hentges (1-4, 7.86 ERA).

The game is slated to begin at 6:10 p.m. ET from Progressive Field in Cleveland. Cincinnati is a -177 favorite (risk $177 to win $100) on the money line in the latest Reds vs. Indians odds from Caesars Sportsbook, while the over-under for total runs scored is 9.5. Before finalizing any Indians vs. Reds picks, check out the latest MLB predictions from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, is 150-122 on top-rated MLB money-line picks through 19 weeks in the 2021 season, returning almost $500. It also had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line MLB picks. Anyone following it has seen some huge returns.

Now, the model has dialed in on Reds vs. Indians and revealed its predictions and best bets. You can visit SportsLine now to see its MLB picks. Here are the MLB odds and betting trends for Indians vs. Reds:

  • Reds vs. Indians money line: Cincinnati -177, Cleveland +162
  • Reds vs. Indians run line: Cincinnati -1.5 (-120)
  • Reds vs. Indians over-under: 9.5 runs
  • CIN: The Reds are 5-0 in their last five games against a team with a losing record
  • CLE: The Indians are 5-2 in their last seven Monday games
Featured Game | Cleveland Indians vs. Cincinnati Reds

Why you should back the Reds

Cincinnati looks to stay hot against Cleveland, who it has beaten in three of five meetings in 2021. Outfielder Jesse Winker has scorched the baseball of late, with three consecutive multi-hit games. In Saturday's 11-3 win over the Pittsburgh Pirates, Winker was 3-for-5 with a double, home run and six RBIs. For the season, he is hitting .310 with 23 homers, 67 RBIs and 75 runs scored.

Infielder Jonathan India has also been a thorn in the side of opposing pitchers. He had a six-game hitting streak snapped on Sunday. During that stretch, he had three multi-hit games, including a 3-for-5 performance with a double and an RBI on Wednesday against Minnesota. He was 2-for-3 with two runs scored and an RBI in Saturday's victory.

Why you should back the Indians

Cleveland is coming off its first series win since mid-July, going 2-1 against the Detroit Tigers over the weekend. Outfielder Bradley Zimmer was 2-for-5 in Sunday's 7-5 win, hitting the tie-breaking two-run homer in the bottom of the seventh inning. For the season, Zimmer is hitting .247 with three homers, 18 RBIs and 20 runs scored. He has hit well against Reds pitching since entering the big leagues in 2017. In six career games against Cincinnati, he is hitting .357 with a double and two RBIs.

Infielder Amed Rosario, who sat out Sunday's game, is expected to be back in the lineup. He has hits in his last four games and in eight of nine. In Saturday's 2-1 loss to the Tigers, Rosario was 2-for-5, his fourth multi-hit game during that stretch. For the season, he is batting .270 with six homers, 32 RBIs and 51 runs scored.

How to make Indians vs. Reds picks

SportsLine's model is leaning over on the run total, as the simulation projects the teams to combine for 10 runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine

So who wins Indians vs. Reds? And which side of the money line has all the value? Visit SportsLine now to see which side to jump on, all from the advanced model that is up almost $500 on top-rated MLB money-line picks in 2021, and find out.