One of the most anticipated fights in the history of the heavyweight division takes place on Saturday when champion Francis Ngannou in the main event of UFC 270. The unification battle tops the MMA showcase from the Honda Center in Anaheim, with the main UFC 270 fight card scheduled for 10 p.m. ET. The fearsome Ngannou is perhaps the heaviest puncher in UFC history and has seen 10 of his 11 wins with the promotion come by knockout. He became the champion last year with a stoppage against Stipe Miocic in their memorable rematch. His first title defense comes against the elusive and slick Gane, who has dominated the opposition while winning all seven of his UFC fights.

Gane is a -160 favorite (risk $160 to win $100), while Ngannou comes back at +140 in the latest Ngannou vs. Gane odds from Caesars Sportsbook. In the co-main event, flyweight champion Brandon Moreno is -170 (risk $170 to win $100) in the latest UFC 270 odds as he takes on former champion Deiveson Figueiredo (+150) in a trilogy fight. Before locking in any UFC 270: Ngannou vs. Gane picks, make sure you check out the MMA picks and betting advice from red-hot SportsLine expert Kyle Marley

Marley won the first-ever "ToutMaster" UFC betting contest sponsored by MMAOddsBreaker and appears regularly on multiple MMA betting and daily Fantasy shows. He watches every single fight for every professional MMA card and does extensive research before each event.

Over the past 35 months, $100 bettors who have followed Marley's picks are up more than $13,000. The accomplished MMA analyst has now connected on 44 of his last UFC 73 main-event picks, a stretch that includes a streak of five straight underdogs in 2020.

Just last week at UFC Fight Night, Marley told SportsLine members to back Calvin Kattar (+200) against Giga Chikadze (-240) in the featherweight showdown in the main event. Kattar's lopsided decision victory gave Marley's followers another easy winner. Anyone who has followed him is way up. You can only see Marley's MMA picks at SportsLine.

UFC 270: Ngannou vs. Gane expert preview

Ngannou, 35, is widely considered the most lethal striker ever to set foot in the Octagon, and even other heavy-handed contenders have been unable to survive the first clean shot he lands.

The Cameroon-born champion's resume is full of first-round knockouts, and his many victims include former champions Cain Velasquez and Junior Dos Santos. What seemed like a sure ascent to the title was halted by a five-round loss to Miocic in January 2018. Ngannou fought his way back and now brings a more complete skill set and five-fight win streak into Saturday's title defense.

Gane (10-0), 31, is a relative newcomer to mixed martial arts following successful stints in numerous disciplines such as kickboxing and Muay Thai fighting. He made his professional MMA debut in August 2018 and immediately caught the attention of observers because of his unusual agility and athleticism to go along with a physique that sometimes pushes the heavyweight limit of 265 pounds.

The French fighter was fast-tracked into high-profile fights because the UFC brass was eager to see if he was as good as advertised. After he dominated and stopped the rugged Lewis in Lewis's hometown of Houston in August, Gane became the interim champion and his matchup with Ngannou looms as one of the most anticipated in the division's history. You can only see who to back at SportsLine.

Top UFC 270 predictions

We'll share one of Marley's UFC 270 picks here: He is going with Trevin Giles (+110) to get the best of Michael Morales (-130) in a matchup of welterweight prospects.

Giles (14-3) came to the UFC as a celebrated and undefeated prospect in December 2017, but suffered back-to-back losses against experienced veterans following a win in his debut. The 29-year-old Texan responded with a three-fight winning streak, but saw that halted with a stoppage loss against rising star Dricus du Plessislast July.

Morales (12-0) is just 21 and will make his UFC debut amid a groundswell of hype following a victory on "Dana White's Contender Series" in September. The Ecuadorian fighter has seen 10 of his 12 professional MMA victories come inside the distance.

"I think Morales could be the real deal one day, but I don't see any big advantages for him on Saturday. Giles can win it anywhere it goes," Marley told SportsLine.

How to make UFC 270 selections

Marley also has strong picks for Ngannou vs. Gane every other bout on the UFC 270 card. He's also backing a fighter who has "looked amazing and pretty unbeatable" to emerge with a dominant victory. Those expert MMA picks are only available at SportsLine

Who wins Ngannou vs. Gane? And how does each fight end? Visit SportsLine now to get detailed picks on every fight at UFC 270, all from the incomparable expert who's up more than $13,000 on MMA in the past 35 months, and find out.

UFC 270 odds, fight card

Ciryl Gane (-160) vs. Francis Ngannou (+140)
Brandon Moreno (-170) vs. Deiveson Figueiredo (+150)
Said Nurmagomedov (-190) vs. Cody Stamann (+170)
Tony Gravely (-240) vs. Saimon Oliveira (+200)
Kay Hansen (-240) vs. Jasmine Jasudavicius (+200)
Matt Frevola (-180) vs. Genaro Valdez (+160)
Rodolfo Vieira (-260) vs. Wellington Turman (+220)
Jack Maddalena (-310) vs. Pete Rodriguez (+255)
Vanessa Demopoulos (-145) vs. Silvana Gomez Juarez (+125)
Charles Jourdain (+400) vs. Ilia Topuria (-500)
Victor Henry (+350) vs. Raoni Barcelos (-430)
Michel Pereira (-275) vs. Andre Fialho (+235)
Michael Morales (-130) vs. Trevin Giles (+110)
Michel Pereira (-270) vs. Andre Fialho (+230)