The Cleveland Cavaliers will take on the Memphis Grizzlies at 8 p.m. ET on Wednesday at the FedExForum. Memphis finished second in the Southwest Division last year at 38-34 and made the playoffs after clinching a play-in berth. Meanwhile, Cleveland placed fourth in the Central Division at 22-50. The Grizzlies lost to the Jazz in the first round of the postseason in five games. 

The teams split their two meetings last season. Memphis is favored by 7.5-points in the latest Grizzlies vs. Cavaliers odds from Caesars Sportsbook, and the over-under is set at 218. Before entering any Cavaliers vs. Grizzlies picks, you'll want to see the NBA predictions from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned almost $9,000 in profit on its top-rated NBA picks over the past two-plus seasons. The model is up almost $600 on its top-rated picks this season and entered the final week of the 2021 NBA Finals on a stunning 100-66 roll on top-rated NBA picks against the spread dating back to last season. Anyone following it has seen huge returns.

Now, the model has set its sights on Grizzlies vs. Cavaliers. You can head to SportsLine to see its picks. Here are several NBA betting lines for Grizzlies vs. Cavaliers:

  • Grizzlies vs. Cavaliers spread: Grizzlies -7.5
  • Grizzlies vs. Cavaliers over-under: 218 points
Featured Game | Memphis Grizzlies vs. Cleveland Cavaliers

What you need to know about the Cavaliers

Evan Mobley, selected third overall in the 2021 NBA Draft, will make his pro debut on Wednesday. He averaged 7.6 rebounds in the preseason while blocking eight shots, and he had a double-double against the Bulls with 15 points and 10 rebounds. Cleveland lost three of five preseason games. 

Ricky Rubio, who was acquired from Minnesota in August, and Lauri Markkanen, who was also acquired from Chicago in August, will play their first games with the Cavaliers on Wednesday. Collin Sexton averaged a career-high 24.5 points per game last year. He opened last season with two games of 25-plus points. 

What you need to know about the Grizzlies

The Grizzlies have lost 21 of 26 season openers. Their last season-opening win was in 2017. Jaren Jackson Jr., who played in only 11 regular season games last year, averaged 18.0 points per game during the preseason. He signed a four-year, $105 million dollar rookie contract extension this week. Memphis finished with a 3-3 preseason record. 

Memphis acquired No. 10 overall pick Ziaire Williams and veteran center Steven Adams from New Orleans as part of a three-team trade with the Hornets in the offseasonThe Grizzlies averaged a franchise record 113.3 points per game last year. 

How to make Grizzlies vs. Cavaliers picks

The model has simulated Grizzlies vs. Cavaliers 10,000 times and the results are in. We can tell you that the model is leaning under, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Grizzlies vs. Cavaliers? And which side of the spread hits in well over 50 percent of simulations? Visit SportsLine now to find out which side of the Grizzlies vs. Cavaliers spread you need to jump on Wednesday, all from the model that has crushed its NBA picks, and find out.