The San Francisco 49ers will attempt to extend their playoff winning streak against Green Bay to four games when they visit the NFC North-champion Packers in the 2022 NFL playoffs on Saturday. San Francisco (11-7) is 4-4 all-time against Green Bay in the NFL playoff bracket, but has won three consecutive meetings, including the 2019 NFC Championship Game. The Packers (13-4) went 8-0 at home during the regular season and have won divisional-round contests on their own field the last two years.

Kickoff from Lambeau Field is set for 8:15 p.m. ET. Green Bay is a 5.5-point favorite in the latest 49ers vs. Packers odds from Caesars Sportsbook, while the over-under for total points scored is 47. Before locking in any Packers vs. 49ers picks, make sure check out the latest NFL playoff predictions and betting advice from SportsLine's proven projection model.

The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters the divisional round of the 2021 NFL playoffs on an incredible 137-97 run on top-rated NFL picks that dates back to the 2017 season. Amazingly, it hasn't missed a top-rated pick since Week 14 of the regular season.

The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Packers vs. 49ers on Saturday and just locked in its NFL playoff picks and predictions. You can visit SportsLine now to see the model's picks. Here are the NFL odds and Divisional round betting lines for 49ers vs. Packers:

  • 49ers vs. Packers spread: Green Bay -5.5
  • 49ers vs. Packers over-under: 47 points 
  • 49ers vs. Packers money line: Green Bay -240, San Francisco +200
  • GB: Packers are 11-1 against the spread in their last 12 games following a straight-up loss 
  • SF: 49ers are 6-1 ATS in their last seven contests as underdogs
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Why the Packers can cover

Lambeau Field was a house of horrors for opponents during the regular season, as Green Bay posted an 8-0 home record, winning by an average of 13.9 points. Including the NFL playoffs, the Packers are 24-3 and have a plus-10 point differential on their own field since Matt LaFleur became head coach in 2019, both of which are best in the NFL in that span. With a win on Saturday, LaFleur will join Jim Harbaugh as the only coaches in the Super Bowl era to reach the conference title game in each of their first three seasons.

Aaron Rodgers, who is tied with Joe Montana (45) for the second-most TD passes in NFL playoff history, made an impressive bid to repeat as MVP in 2021, as he led the league with a 111.9 passer rating and also had the best touchdown-interception ratio (37-4). The 38-year-old future Hall-of-Famer threw for 4,115 yards, marking the fourth consecutive season and 10th time in his career he has eclipsed the 4,000-yard plateau. Rodgers finished the regular season strong, throwing 20 touchdown passes and no interceptions over his final seven contests.

Why the 49ers can cover

Including its wild-card contest at Dallas last weekend, San Francisco has allowed an average of 18 points while winning eight of its last 10 games, the fourth-lowest total in the NFL. It has won three straight on the road, all against playoff teams, and has registered at least three sacks in seven consecutive contests. Quarterback Jimmy Garoppolo is 3-0 when the 49ers are underdogs this season and 13-5 as a starter for underdog teams, giving him the best winning percentage (72 percent) in the league since the start of the 2000 season.

Including the NFL playoffs, the 30-year-old quarterback has gone 20-6 on the road over his career for a winning percentage of 77 percent, the second-best mark in the NFL since the 1970 merger behind Patrick Mahomes (26-7, 79 percent). The 49ers have excelled with Garoppolo under center during Kyle Shanahan's tenure as coach, going 34-15 (including the postseason), as opposed to 8-28 with other signal-callers. San Francisco has the distinct advantage in the kicking game, as Robbie Gould is 18-for-18 on field goals, the most without a miss in the Super Bowl era, and 31-for-31 on extra points during his postseason career.

How to make Packers vs. 49ers picks

SportsLine's model is leaning Under on the point total. In fact, it's calling for 46 total points. It also says one side of the spread cashes in well over 50 percent of simulations. You can only get the model's 49ers vs. Packers picks at SportsLine.

So who wins Packers vs. 49ers on Saturday in the NFL playoffs 2022? And which side of the spread cashes well over 50 percent of the time? Visit SportsLine now to see which side of the Packers vs. 49ers spread to be all over, all from the advanced model that is up more than $7,500 on its top-rated NFL picks, and find out.