The Jacksonville Jaguars will take on the Arizona Cardinals at 1 p.m. ET on Sunday at TIAA Bank Field. The Jaguars are 0-2, while Arizona is 2-0. Jacksonville lost to the Denver Broncos last week, 23-13. Arizona edged Minnesota, 34-33. 

The Jaguars have lost 17 consecutive games. Arizona is favored by 7.5 points in the latest Jaguars vs. Cardinals odds from Caesars Sportsbook, and the over-under is set at 51.5. Before entering any Cardinals vs. Jaguars picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,800 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 3 of the 2021 season on an incredible 122-81 run on top-rated NFL picks that dates back to the 2017 season. 

The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Jaguars vs. Cardinals. You can head to SportsLine to see its picks. Here are several NFL betting lines for Cardinals vs. Jaguars:

  • Jaguars vs. Cardinals spread: Cardinals -7.5
  • Jaguars vs. Cardinals over-under: 51.5 points
Featured Game | Jacksonville Jaguars vs. Arizona Cardinals

What you need to know about the Jaguars

Trevor Lawrence completed 14 of 33 attempts for 118 yards with a touchdown and two interceptions against Denver, He averaged only 3.58 yards per passing attempt. Lawrence has thrown five interceptions in his first two NFL starts. After Jacksonville's opening TD drive the Jaguars only totaled 106 yards for the rest of the game. 

James Robinson has 72 rushing yards with no TDs after two games. He does have 80-plus scrimmage yards in four of his past five home games. Marvin Jones has five-plus catches, 50-plus receiving yards and a TD in his last three games. 

What you need to know about the Cardinals

Arizona escaped with a win last week when Minnesota missed a 37-yard field-goal attempt in the final seconds. Kyler Murray  passed for three TDs and 400 yards on 36 attempts in addition to rushing for one TD and 31 yards. He is Is the first-ever NFL player with three-plus passing TDs and a rushing TD in each of the first two games of a season.

DeAndre Hopkins has caught a TD pass in his last two games, but he will be a game-time decision this week because of concerns about his ribs. Rookie Rondale Moore had seven receptions for a team-high 114 yards and his first career TD vs. Minnesota.  

How to make Jaguars vs. Cardinals picks

The model has simulated Jaguars vs. Cardinals 10,000 times and the results are in. The model is leaning under on the total, and it's also generated a point-spread pick that is hitting in over 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Jaguars vs. Cardinals? And which side of the spread hits more than 60 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.