The Week 3 NFL schedule features several intriguing matchups, one being a battle of undefeated AFC East teams as the Buffalo Bills visit the Miami Dolphins. It's no surprise that Buffalo is 2-0 since it entered the season as the favorite to win the Super Bowl at Caesars Sportsbook. The Bills lead the league in scoring (36 points per game) and are second in points allowed (8.5), but Miami has surprised many thus far as it is tied for fourth at 31 points per game, while Tua Tagovailoa shares the NFL lead with seven touchdown passes. The Bills are 4.5-point favorites in the Week 3 NFL odds at Caesars Sportsbook. Other Week 3 NFL spreads include Tampa Bay as a 1.5-point home favorite against Green Bay and Arizona as a 3.5-point home underdog versus the defending Super Bowl champion Los Angeles Rams. Which Week 3 NFL lines should you target with your Week 3 NFL bets? Before you make any Week 3 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2022 NFL season on an incredible 139-102 run on top-rated NFL picks that dates back to the 2017 season.  

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 3. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 3 NFL picks at SportsLine

Top Week 3 NFL picks

After simulating every game 10,000 times, the model is high on the Cincinnati Bengals (-6) to win and cover against the New York Jets on Sunday. Cincinnati has yet to make an interception this season, but there's a strong chance that will change considering how often New York quarterback Joe Flacco has thrown the football in his first two games. The 37-year-old attempted a whopping 59 passes against Baltimore in the Jets' season-opener and had 44 in Week 2 versus Cleveland.

The Bengals know Flacco well, as the former Baltimore signal-caller has the most losses by a starting quarterback (11) against Cincinnati in NFL history. Flacco has thrown 25 interceptions in 20 career games versus the Bengals, nearly twice as many as his second-highest total against an opponent (13 vs. Cleveland). New York is 0-6 against the spread at home in September in the past five seasons, one reason why the model has the Bengals covering the spread in almost 60% of simulations. See which other NFL parlay picks to make here. See which other NFL parlay picks to make here.

How to make Week 3 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including backing a shocking team even though they were dominated last week. You can only see the model's NFL Week 3 best bets and parlay at SportsLine

What are the model's top Week 3 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 3 NFL best bets from a model on a 139-102 run on its top-rated picks, and find out.