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No. 6 Villanova (4-2) and Pennsylvania (3-6) will battle it out in a non-conference matchup on Wednesday night. The Wildcats bounced back from their loss to No. 2 Purdue as they then blew out La Salle University 72-46 to get back into the win column. The Quakers have dropped two straight games. In their last matchup, they fell to No. 10 Arkansas 76-60.

Tip-off is at 7 p.m. ET from The Palestra. Villanova is an 18-point favorite, while the over-under or total number of points Vegas thinks will be scored, is 138 in the latest Villanova vs. Pennsylvania odds. Before locking in any Villanova vs. Pennsylvania picks, be sure to check out the college basketball predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,100 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Villanova vs. Penn and just locked in its CBB picks and predictions. You can visit SportsLine now to see the model's picks. Here are the college basketball odds and betting lines for Villanova vs. Pennsylvania:

  • Villanova vs. Pennsylvania spread: Villanova -18
  • Villanova vs. Pennsylvania over-under: 138 points
  • Villanova vs. Pennsylvania money line: Pennsylvania +900, Villanova -1700
  • PENN: Quakers are 5-1 ATS in their last 6 games vs. a team with a winning straight-up record
  • NOVA: Wildcats are 4-1 ATS in their last 5 Wednesday games
Featured Game | Pennsylvania Quakers vs. Villanova Wildcats

Why Villanova can cover 

Junior guard Justin Moore leads the Wildcats in scoring. He is averaging 16.3 points, 4.2 rebounds and is shooting 47 percent from beyond the arc. Moore scored at least 13 points in five consecutive games to start the season. Against Mount St. Mary's, he finished with a season-high 27 points as he shot 6-of-8 from 3-point range.

Guard Collin Gillespie is second on the team with 15.5 points while dishing out 4.2 assists and grabbing 1.7 steals per game. Gillespie has scored double-digit points and knocked down at least two 3-pointers in all six games this season. The Pennsylvania native has also snagged two steals in four games thus far. Against Howard, Gillespie logged a season-high 21 points and shot 5-of-12 from 3-point range. 

Why Pennsylvania can cover

Sophomore guard Jordan Dingle is averaging a team-high 19.6 points with 3.3 rebounds, and 3.3 assists per game. Dingle has logged at least 20 points in five games this year, including three straight 20-point performances to open the season. His best game thus far came against Utah State when he finished with a season-high 31 points, five boards, and four assists. The New York native shot 10-of-24 from the field and 8-of-10 from the free-throw line.

Junior guard Jonah Charles is second on the squad with 10.7 points per game and is also shooting 38 percent from 3-point land. Charles scored above 10 points and hit at least four 3-pointers in four games this season. The New Jersey native kicked off the year with back-to-back games with double-digit points. Against Florida State, he scored 12 points and hit four 3Ps an then followed that up with 18 points against George Mason. Charles hit a season-high six 3-pointers in that matchup. 

How to make Villanova vs. Pennsylvania picks

SportsLine's model is leaning over on the point total, projecting the teams to combine for 150 points. The model also says one side of the spread hits in almost 70 percent of simulations. You can only see the model's picks at SportsLine.

So who wins Villanova vs. Pennsylvania? And which side of the spread hits in almost 70 percent of simulations? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its college basketball picks, and find out.