The Villanova Wildcats haven't had much trouble against the Xavier Musketeers over the years, going 31-6 in the all-time series. Villanova posted its fourth consecutive victory against Xavier and ninth in 10 meetings when it defeated the Musketeers 71-58 at home on Dec. 21. The No. 14 Wildcats (11-4, 4-1) attempt to extend the winning streak when they visit 17th-ranked Xavier (12-2, 2-1) on Wednesday for a Big East battle. The Musketeers, however, have won eight of their last nine contests and are a perfect 9-0 at home this season.

Tip-off from the Cintas Center in Cincinnati is set for 6:30 p.m. ET. The Musketeers are 1.5-point favorites in the latest Villanova vs. Xavier odds at Caesars Sportsbook, while the over-under for total points scored is 138. Before making any Xavier vs. Villanova picks, be sure to see the college basketball predictions and betting advice from SportsLine's proven model

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.
Now, the model has set its sights on Villanova vs. Xavier and locked in its picks and predictions. You can visit SportsLine now to see the model's picks. Here are several college basketball odds and betting lines for Xavier vs. Villanova:

  • Villanova vs. Xavier spread: Xavier -1.5
  • Villanova vs. Xavier over-under: 138 points
  • Villanova vs. Xavier money line: Xavier -120, Villanova +100
  • NOVA: The Wildcats are 5-1 against the spread in their last six games following a straight-up win
  • XAV: The Musketeers are 7-1 ATS in their last eight home contests
Featured Game | Xavier Musketeers vs. Villanova Wildcats

Why Villanova can cover

It's no surprise the Wildcats have been on a roll since they've received some superb performances since Christmas. After Collin Gillespie was named the Big East Player of the Week on Jan. 3, Justin Moore received the honor this past Monday. A junior guard, Moore scored 22 points in a victory against Creighton last Wednesday, his first 20-point performance since he recorded 27 versus Mount St. Mary's in the season opener, and followed with 21 points and seven rebounds in Saturday's 79-64 triumph over DePaul.

Moore also was Villanova's leading scorer in the previous meeting with Xavier as he recorded 17 points on 7-of-11 shooting, including 3-of-6 from 3-point range. He is producing 15.7 points per contest to rank second on the team in scoring. Gillespie, who registered a season-high 28 points in the win against the Blue Demons, is averaging 16.9 points and has been held under 10 just once this season.

Why Xavier can cover

The Musketeers are averaging 79.8 points in their nine home contests and have scored 80 or more on five occasions. They have recorded a total of 345 points over their last four on their own court while allowing 247 in that span. Four players are averaging at least 10 points for Xavier this season, with Nate Johnson leading the way at 12.7 per game.

Johnson and fellow senior guards Paul Scruggs and Adam Kunkel have accounted for 42 percent of the Musketeers' points in 2021-22 and 40 percent over their last five contests. Kunkel came off the bench to score a team-high 25 points on 8-of-12 shooting in Xavier's 87-72 victory at Butler on Friday, its first game in 17 days. Scruggs, who leads the team in assists (4.3), registered 16 points, seven rebounds and six assists in the triumph.

How to make Xavier vs. Villanova picks

The model is leaning over on the total, predicting 139 combined points. It also says one side of the spread hits in well over 50 percent of simulations. You can only get the model's college basketball picks at SportsLine

So who wins Villanova vs. Xavier? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that has returned over $2,200 on its college basketball picks the last five-plus years, and find out.