Owners of Bears running back Khalil Herbert were given a lift last week following the news of an ankle injury to David Montgomery early on against the Houston Texans. If they were fortunate enough to have been playing Herbert, they ended Week 3 with the top-scoring Fantasy running back. Herbert will be the starter for Chicago against the Giants this week and returns as one of the top players in the Week 4 Fantasy football rankings.

The Giants have given up the eighth-most rushing yards this season (415), but have Saquon Barkley in their backfield, who is one of the biggest no-brainer Week 4 Fantasy football picks on Sunday. The Giants' receivers have been beat up and ineffective, while the Bears have given up 471 rushing yards this season, making Barkley a prime candidate to go off atop the Fantasy football RB rankings. Before you lock in your lineups, be sure to check out the Week 4 Fantasy football rankings from the advanced computer model at SportsLine.

When it comes to ranking players, SportsLine's model beat human experts in Fantasy football for the past several seasons especially when there were big differences in ranking. Over the course of a season, that could literally be the difference between winning your league or going home empty-handed.

Last week, the model was extremely high on Jaguars running back James Robinson, saying he'd finish as a top-10 player at his position. The result: Robinson rushed 17 times for 100 yards and a touchdown, while also catching all three of his targets for 16 yards in Jacksonville's win over the Chargers. Anybody who had him in their lineup was well on their way to a huge week.

Now, the model, which simulates every NFL game 10,000 times, has revealed its Fantasy football rankings for Week 4 of the 2022 NFL season. Head to SportsLine now to see them.

Top Week 4 Fantasy football picks 

One player the model is high on this week: Lions running back Jamaal Williams. Even with D'Andre Swift available last week against the Vikings, Williams finished with 87 yards and two touchdowns on 20 carries for Detroit. This week, he will be the primary option against a Seattle defense that is tied with Chicago for the second-most rushing yards allowed this season.

The Lions are favored and running the ball to control the pace of the game will be key to head coach Dan Campbell's game plan to preserve a win. The model projects Williams to get another healthy share of the offense on Sunday, which is why he is predicted to finish as a top-20 Fantasy back this weekend. See who else to target here.

And a massive shocker: Raiders wide receiver Davante Adams, who's scored a touchdown in every game this season, stumbles big-time and doesn't even crack the top 20 at his position. After spending his first eight seasons in Green Bay, Adams was traded to the Las Vegas Raiders in the offseason. In his first game as a Raider, Adams hauled in 10 receptions for 141 yards and a touchdown against the Chargers. However, the veteran has recorded only seven receptions for 48 yards across his last two contests.

Adams and the Raiders will now face a stingy Denver Broncos defense. The Broncos are giving up just 170.3 passing yards per game this season, the third-best mark in the NFL. Denver has also allowed just one passing touchdown in its last two games, which doesn't bode well for Adams' Fantasy value this week. With such a tough matchup on Sunday, Adams is a player to consider putting on the bench in Week 4. See who else to fade here.

How to set Week 4 Fantasy football rankings

The model is also calling for a surprising quarterback you aren't even thinking about to finish in the top 10 of its Week 4 Fantasy football rankings. This pick could be the difference between winning big and going home with nothing. You can only see who it is here.

So who should you start and sit this week? And which surprising quarterback could lead you to victory? Visit SportsLine now to get Week 4 Fantasy football rankings for every position, plus see which QB is going to come out of nowhere to crack the top 10, all from the model that has outperformed experts big-time.