The Milwaukee Brewers' offense was running on all cylinders when the Chicago Cubs were in town back in late April, producing 20 runs and 25 hits over the first two contests of the three-game series. Milwaukee belted nine home runs in those outings, both victories, while limiting Chicago to one run in each. The National League Central-leading Brewers hope for a similar result on Monday as they host the division-rival Cubs in the opener of a three-game set. Milwaukee (46-35) posted a 2-0 victory at Pittsburgh on Sunday to conclude a 4-2 road trip, while Chicago (32-47) is coming off a 4-2, 11-inning home loss to Boston that ended its season high-tying four-game winning streak.

First pitch at American Family Field is set for 4:10 p.m. ET. Milwaukee is the -145 money-line favorite (risk $145 to win $100) in the latest Brewers vs. Cubs odds from Caesars Sportsbook, while Chicago is the +122 underdog. The over-under for total runs scored is 8.5. Before making any Cubs vs. Brewers picks, you need to see the MLB predictions and betting advice from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. and it is 271-232 on top-rated MLB money-line picks since the start of the 2021 season, returning well over $500 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Cubs vs. Brewers, and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for Brewers vs. Cubs:

  • Brewers vs. Cubs money line: Milwaukee -145, Chicago +122
  • Brewers vs. Cubs over-under: 8.5 runs
  • Brewers vs. Cubs run line: Milwaukee -1.5 (+130)
  • MIL: The Brewers have scored seven or more runs in four of the last seven meetings between the teams
  • CHC: The Cubs have recorded 33 runs over their last five road games
  • Brewers vs. Cubs picks: See picks at SportsLine
Featured Game | Milwaukee Brewers vs. Chicago Cubs

Why you should back the Brewers

The Cubs won't have to deal with Hunter Renfroe, who is 6-for-22 with three home runs and five RBIs against them this season but is sidelined with a calf injury. However, they can't avoid Christian Yelich, a former NL MVP who enters the series with a 12-game hitting streak. The 30-year-old outfielder also has performed well at the plate against Chicago in 2022, going 9-for-31 with a double, a triple, two homers and six RBIs.

Yelich has been Milwaukee's best hitter against Chicago starter Justin Steele, going 4-for-9 lifetime versus the left-hander. Another member of the Brewers who has teed off against the Cubs is Rowdy Tellez, who is tied for first on the club with 16 blasts and leads it with 53 RBIs. The 27-year-old first baseman has gone 10-for-31 with a pair of home runs and seven RBIs versus Chicago this campaign.

Why you should back the Cubs

Chicago has been getting solid production of late from Patrick Wisdom, who leads the team with 17 home runs and 45 RBIs. The 30-year-old third baseman has gone deep three times and driven in eight runs over his last four contests after notching just one RBI in his previous six games. Nico Hoerner has hit safely in 10 of his last 11 outings, registering seven multi-hit performances during that stretch.

Steele is riding a six-start unbeaten streak during which he has posted a pair of victories and yielded three runs or fewer on five occasions. The 26-year-old southpaw picked up the win against Cincinnati on Wednesday after giving up just one run while notching six strikeouts over six frames. Steele had one of his best outings of 2022 versus the Brewers on Apr. 9, when he scattered four hits over five scoreless innings en route to victory in his season debut. 

How to make Brewers vs. Cubs picks

SportsLine's model is leaning under on the total, projecting eight combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Cubs vs. Brewers? And which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.