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The New York Yankees (56-20) travel to take on the Houston Astros (47-27) on Thursday night. Both teams sit in first place in their respective divisions. On Wednesday, the Astros defeated the Mets 2-0 and secured their second win in a row. The Yankees just swept the Oakland Athletics in their last series. Luis Severino (4-2, 3.38 ERA) is starting for New York, while Luis Garcia (5-5, 3.68 ERA) is on the mound for Houston.

First pitch is set for 6:10 p.m. ET at Minute Maid Park in Houston. Caesars Sportsbook lists New York as the -125 money-line favorite (risk $125 to win $100) in the latest Astros vs. Yankees odds, while Houston is a +105 underdog. The over-under for total runs scored is 8. Before making any Yankees vs. Astros picks, be sure to check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 59-51 run on top-rated MLB money-line picks through 12 weeks. This is the same model that pegged the 2021 Atlanta Braves as one of three best bets to win it all last season at +1000. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Yankees vs. Astros, and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for Astros vs. Yankees:

  • Yankees vs. Astros money line: New York -125, Houston +105
  • Yankees vs. Astros run-line: Houston +1.5 (-165)
  • Yankees vs. Astros over-under: 8 runs
  • Yankees vs. Astros tickets: See tickets at StubHub
  • HOU: Astros are 22-7 in their last 29 Thursday games
  • NYY: Yankees are 6-0 in their last six Thursday games
  • Yankees vs. Astros picks: See picks here
Featured Game | Houston Astros vs. New York Yankees

Why you should back the Astros

Right fielder Kyle Tucker owns a nice combination of sure hands and home run power. Tucker generates plenty of bat speed, and the 25-year-old is hitting .256 with 15 home runs and 51 RBI. On June 28, he went 1-for-3 with a three-run homer.

Third baseman Alex Bregman is a good contact hitter who has tremendous bat speed. Bregman can place the ball into any gap with his effortless swing. The two-time All-Star is a versatile defender who throws an accurate ball across the diamond. Bregman is hitting .241 with nine home runs and 36 RBI.

Why you should back the Yankees

Outfielder Giancarlo Stanton has big-time power when he's at the plate. Stanton owns good pitch recognition skills and consistently produces runs for the Yankees. The four-time All-Star can play either corner outfield position and owns a rocket of an arm. Stanton is tied for eighth in home runs (19) and tied for ninth in RBIs (52).

Third baseman DJ LeMahieu is an all-around player. LeMahieu makes consistent contact and has the athleticism to make difficult plays on the defensive end. The three-time All-Star is batting .262 along with seven home runs and 31 RBIs. In his last outing, LeMahieu went 2-for-3 with two singles and two runs scored. 

How to make Astros vs. Yankees picks

SportsLine's model is leaning over on the total, projecting 8.8 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Yankees vs. Astros? And which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.