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The San Antonio Spurs and the Houston Rockets are set to square off in a Southwest Division matchup at 8:30 p.m. ET Wednesday at the AT&T Center. The Spurs are 15-25 overall and 7-10 at home, while Houston is 11-31 overall and 4-18 on the road. San Antonio was without three starters in its 111-96 loss to the Knicks on Monday. 

San Antonio is favored by 6.5 points in the latest Spurs vs. Rockets odds from Caesars Sportsbook, while the over-under is set at 231. Before entering any Rockets vs. Spurs picks, you'll want to see the NBA predictions from the model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model enters Week 13 of the 2021-22 NBA season on a stunning 52-28 roll on all top-rated NBA picks, returning almost $2,000. Anyone following it has seen huge returns.

Now, the model has set its sights on Spurs vs. Rockets. You can head to SportsLine to see its picks. Here are several NBA betting lines for Rockets vs. Spurs:

  • Spurs vs. Rockets spread: Spurs -6.5
  • Spurs vs. Rockets over-under: 231 points
Featured Game | San Antonio Spurs vs. Houston Rockets

What you need to know about the Spurs

San Antonio wrapped up a disappointing seven-game road trip with a 111-96 loss to the Knicks on Monday. The Spurs finished the road trip with a 1-6 record and were without six of their regular rotation players on Monday due to COVID-19. Starters Derrick White, Doug McDermott and Keldon Johnson remain sidelined indefinitely, as does Devin Vassell.

Guard Dejounte Murray led San Antonio with 24 points in the loss, while Lonnie Walker IV added 15. Murray is the team's leading scorer this season, averaging 18.4 points and 8.2 rebounds. Johnson and White are the second and third-leading scorers, respectively. The Spurs have covered the spread in 10 of their last 13 games against Western Conference opponents. 

What you need to know about the Rockets

Houston is not in good form either, having lost three straight games and 11 of its past 12. The Rockets came up short in a 111-91 final at home against Philadelphia on Monday. They were without veteran guard Eric Gordon due to right groin tightness, but he is expected to play on Wednesday night, while Armoni Brooks (protocols) and Alperen Sengun (ankle) are questionable.

The Rockets are now heading on the road for their next five games. Fifth-year power forward Christian Wood leads Houston with 17.1 points and 10.0 rebounds per game, while shooting guard Jalen Green is adding 15.2 points. Houston has only covered the spread once in its last 12 games. 

How to make Spurs vs. Rockets picks

The model has simulated Spurs vs. Rockets 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Rockets vs. Spurs? And which side covers almost 60 percent of the time? Visit SportsLine now to find out, all from the model that has crushed its NBA picks.