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The ankle issues continue to pile up for the Indianapolis Colts. All-Pro left guard Quenton Nelson was taken into the medical tent and later carted off the field in the second quarter of Sunday's game against the Titans after sustaining an ankle injury. NFL Network's Ian Rapoport reports that the injury is believed to be a high ankle sprain. X-Rays were negative and, he will undergo further testing to determine the timetable for a return.

On third-and-1, quarterback Carson Wentz handed off to running back Jonathan Taylor. The play resulted in a two yard gain but it cost them their star lineman and a critical component of Wentz's protection. Although left tackle Eric Fisher made his AFC South debut last weekend, the team is without right tackle Braden Smith in Week 3. Nelson has never missed a start in the NFL. Chris Reed, who started 14 games for Carolina in 2020, replaced Nelson.

Wentz is playing on two injured ankles, so his mobility is limited. Strong offensive line play was important for allowing the quarterback enough time in the pocket to push the ball downfield.

Nelson had been dealing with a right foot injury during training camp. Head coach Frank Reich said at the time that it was an issue likely present at birth.

"It was something that was always there, something you just never knew, then all of a sudden, here it is," Reich said in August.

Indianapolis opened the season with two losses to NFC contenders Seattle and Los Angeles. No team in the AFC South entered Sunday's game with more than one victory, however.