Steelers vs. Panthers odds, line: Thursday Night Football picks, predictions from advanced computer model on 70-43 roll

Dynamic quarterbacks square off on Thursday Night Football when veterans Cam Newton and Ben Roethlisberger square off. Kickoff for Steelers vs. Panthers from Heinz Field is at 8:20 p.m. ET. These teams enter on strong winning streaks, as Pittsburgh has won four straight games, while Carolina has been victorious in its previous three. Temperatures are expected to be in the 40s with light winds, and Pittsburgh is a 3.5-point favorite in the latest Steelers vs. Panthers odds. The Over-Under, which opened at 50, is now 51. The Steelers are -180 on the money line (risk $180 to win $100), while the Panthers are +162 (risk $100 to win $162). Before you make any Steelers vs. Panthers picks, check out what the advanced computer model at SportsLine has to say.

In a straight-up, pick'em format, their proprietary computer model went 176-80 last season and beat over 95 percent of CBS Office Pool players in 2016 and 2017, performing better than 98 percent of experts tracked by NFLPickWatch.com during that span. Additionally, it went 48-34 on all A-rated picks last season, and $100 bettors who followed it the past two seasons are up nearly $4,000.

The model has continued to nail its top-rated picks in 2018, entering Week 10 on a strong 8-0 run. For the season, it is now 22-9 on all top-rated picks, extending its two-year run to a blistering 70-43. And when it comes to all straight-up picks, the model is 89-43 this season, again ranking in the top 10 on NFLPickWatch.com. Anybody who has been following it is way, way up. 

Now, the model has simulated the Panthers vs. Steelers 10,000 times. We can tell you it's leaning over, but it also has generated a spread pick that hits over 50 percent of the time. You can only see that one at SportsLine. 

The model has factored in that while Roethlisberger is performing at an elite level with 16 touchdown tosses and over 2,500 passing yards, Antonio Brown and JuJu Smith-Schuster have helped carried the load. Combined, the team's top two wideouts have amassed well over 1,200 yards and 11 TD receptions. Smith-Schuster is tops in both receptions (53) and receiving yards (672), but Brown has found pay dirt nine times. Tight end Vance McDonald has become Roethlisberger's safety valve with 26 catches for 346 yards.

But just because the Steelers have been on a tear doesn't mean they will cover against Carolina. 

The model knows that Newton's accuracy in 2018 is at one of his highest levels ever. He's completing over 67 percent of his attempts for 1,893 yards. In addition to his 15 touchdown passes -- two of which were against Tampa Bay -- he has rushed for another four. He also has 342 rushing yards.

Carolina asserts its will with an imposing ground attack that produces 143.9 yards per game. Second-year star Christian McCaffrey leads the Panthers with 502 rushing yards and 46 catches. He has also found the end zone five times. Wideout Devin Funchess is the primary deep threat with a team-high seven receptions of 20 yards or more.

Who wins Panthers vs. Steelers? And which side covers in over 50 percent of simulations? Visit SportsLine now to see which side you need to be all over, all from the incredible computer model that has returned nearly $4,000 to $100 bettors.

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