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When the Cleveland Browns (3-2) host the Arizona Cardinals (5-0) on Sunday afternoon, the result may have more to do with who is not on the field than who is. Arizona head coach Kliff Kingsbury tested positive for COVID-19 this week and will not be on the sidelines for the Cardinals. Meanwhile, running back Nick Chubb is unavailable for Cleveland with a calf injury.

Kickoff from FirstEnergy Stadium in Cleveland is set for 4:05 p.m. ET. Cleveland is a three-point favorite in the latest Browns vs. Cardinals odds from Caesars Sportsbook, while the over-under for total points scored is set at 48. Before entering any Cardinals vs. Browns picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 6 of the 2021 season on an incredible 125-83 run on top-rated NFL picks that dates back to the 2017 season. 

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY up.

Now, the model has set its sights on Browns vs. Cardinals. You can head to SportsLine to see its picks. Here are several NFL betting lines for Cardinals vs. Browns:

  • Browns vs. Cardinals spread: Browns -3
  • Browns vs. Cardinals over-under: 48 points
Featured Game | Cleveland Browns vs. Arizona Cardinals

What you need to know about the Browns

Even without Chubb, the Browns should be able to move the ball on the ground against Arizona. The Cardinals will get a healthy dose of Kareem Hunt, who could cut up an Arizona defense that has allowed the fifth-most rushing yards in the NFL. Hunt should factor into the passing game as well, as Arizona has allowed opposing running backs to catch 25 passes for 204 yards this season.

Cleveland had hoped to activate Jarvis Landry off of injured reserve for the game, but he will sit for another week. The Browns' tight ends have taken on a bigger role in the passing game, but Arizona has allowed the third-fewest receiving yards to the TE position in 2021. Wide receiver Donovan Peoples-Jones stepped up last week with five catches for 70 yards in Week 5 for Cleveland, and could be in for another big week against a Cardinals defense looking to stack the box against Hunt.

What you need to know about the Cardinals

The Cardinals have started 5-0 for the first time since the 1974 season. DeAndre Hopkins' 9-yard TD catch with 5:13 left gave Arizona a 17-7 lead on its way to the victory. The Cardinals stopped San Francisco four times on fourth down conversion attempts. Kyler Murray passed for 239 yards and a TD. 

Arizona head coach Kliff Kingsbury tested positive for COVID-19 and will not be on the sideline for Sunday's game. Quarterbacks coach Cam Turner and defensive lineman Zach Allen also tested positive and will miss the game vs, Cleveland. Defensive coordinator Vance Joseph and special teams coordinator Jeff Rodgers are expected to share head coaching duties. The status of Chandler Jones, who tested positive earlier this week, is uncertain. 

How to make Cardinals vs. Browns picks

The model has simulated Browns vs. Cardinals 10,000 times and the results are in. It is leaning under on the total, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Browns vs. Cardinals? And which side of the spread hits well over 50 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.