After losing eight straight games to the Rams, the Cardinals finally got a victory over their divisional-rivals in Week 4. The two NFC West squads will meet again in Week 14 on Monday Night Football, and another win by Arizona would allow it to clinch a postseason berth. Kyler Murray and DeAndre Hopkins both returned last week and will be highly popular options in the NFL DFS player pool.

In Chase Edmonds' absence, Cardinals running back James Conner has been a touchdown machine with six scores over the last four games. Which Cardinals could find the end zone on Monday Night Football and come through for your NFL DFS lineups? Before locking in your NFL DFS picks for Rams vs. Cardinals, be sure to check out the NFL DFS advice, strategy and projections from SportsLine daily Fantasy expert Mike McClure.

McClure is a legendary professional DFS player with almost $2 million in career winnings. His methodology has led to enormous cashes on FanDuel and DraftKings. He took down two high-stakes tournaments on FanDuel in 2020 and recorded a pair top-10 finishes in tournaments with over 130,000 entrants on DraftKings. His lineups also finished inside the top 1 percent in more than a dozen other tournaments last season.

He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine.

Now, McClure has turned his attention to Rams vs. Cardinals and locked in his top daily Fantasy football picks. You can only see them by heading to SportsLine.

Top NFL DFS picks for Rams vs. Cardinals

One of McClure's top NFL DFS picks for Monday Night Football is Rams running back Sony Michel. The former Patriot got the start last week with Darrell Henderson (quad) not seeing the field and he responded with a season-high 121 yards along with a score. It was the second-highest rushing total of Michel's regular-season career and his most in more than three years.

Henderson will be out again on Monday Night Football with COVID-19, giving Michel another workhorse opportunity. The Cardinals are allowing 4.7 yards per carry, which is third-worst in the NFL, so you can count on Michel to exploit Arizona in place of Henderson.

McClure's optimal NFL DFS strategy also includes rostering Cardinals receiver DeAndre Hopkins, who returned last week after missing three games due to injury and scored his eighth touchdown of the season. Despite missing one-quarter of the season, Hopkins still ranks fourth in the NFL in receiving touchdowns.

Hopkins hasn't been quite as prolific this year due to all of the playmakers in Arizona's offense, but he's still bankable around the end zone. Inside the 10-yard-line, Hopkins has four TD catches, which is more than A.J. Green, Christian Kirk and Rondale Moore combined. Thus, he clearly has the attention of quarterback Kyler Murray approaching the goal line.

How to set NFL DFS lineups for Cardinals vs. Rams

McClure is also targeting an undervalued player who is set to explode for huge numbers on Monday Night Football. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is here

So who is Mike McClure putting in his optimal NFL DFS lineups for Monday Night Football? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from a daily Fantasy expert with nearly $2 million in winnings, and find out.