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The New York Jets will try to build on last week's success when they take on the Indianapolis Colts on Thursday Night Football. The Jets (2-5), who are 0-4 away from home this year, are 9-35 on the road over the past five-plus seasons. The Colts (3-5), who are just 1-3 at home in 2021, are 25-19 at Lucas Oil Stadium since 2016. Indianapolis leads the all-time regular season series 42-29, but New York has a 3-1 edge in postseason games.

Kickoff from Lucas Oil Stadium in Indianapolis is set for 8:20 p.m. ET. Indianapolis is a 10-point favorite in the latest Colts vs. Jets odds from Caesars Sportsbook, while the over-under for total points scored is 45. Before you make any Jets vs. Colts bets or Thursday Night Football predictions, make sure you check out what SportsLine NFL expert Larry Hartstein has to say.

SportsLine's senior analyst and Early Edge podcast regular enters the 2021 season 351-291 all-time on NFL sides returning more than $2,200 for $100 bettors, including a 326-280 against the spread mark. 

In addition, Hartstein has an amazing 19-8-3 record on his last 30 against-the-spread picks involving Indianapolis, returning more than $1,000. Anyone who has followed him is way up.

Now, White has broken down Jets vs. Colts from every angle and just locked in his NFL expert picks. You can head to SportsLine to see Hartstein's TNF picks. Here are the NFL odds and betting lines for Colts vs. Jets: 

  • Colts vs. Jets spread: Indianapolis -10
  • Colts vs. Jets over-under: 45 points 
  • Colts vs. Jets money line: New York Jets +400, Indianapolis -550 
  • NYJ: Jets are 5-2 against the spread in their last seven games in November 
  • IND: Colts are 4-1 ATS in their last five games overall
Featured Game | Indianapolis Colts vs. New York Jets

Why the Colts can cover

With wide receiver T.Y. Hilton out with a concussion, the Colts will turn to Michael Pittman Jr. to fill the void. Pittman had a career-high 10 catches for 86 yards and two touchdowns last week against the Titans. He is looking for his third game in a row with 85 or more receiving yards and a receiving touchdown. Pittman leads the Colts in receiving with 45 receptions for 594 yards (13.2 average) and four TDs. He has eight explosive plays of 20 or more yards with 27 first-down conversions.

Tight end Mo Alie-Cox has been a key weapon in the red zone and has 13 catches for 177 yards (13.6 average) and four touchdowns. He has three explosive plays and converted nine first downs. He had 50 receiving yards and a touchdown catch in the last meeting with the Jets. He is looking for his third game in a row against an AFC East foe with a touchdown catch.

Why the Jets can cover 

Wide receiver Braxton Berrios had a touchdown in Week 8 and will be looking for his second game in a row against the Colts with a receiving touchdown. For the season, Berrios has 18 receptions for 169 yards (9.4 average) and one touchdown. He has three explosive plays of 20 yards or more and converted six first downs. His best game this season was a seven-catch, 73-yard performance against the New England Patriots on Sept. 19.

Defensive lineman Shaq Lawson has been playing well. Last week against Cincinnati, Lawson had two pass breakups and his first career interception. For the season, he has registered 12 tackles, including 10 solo, with four tackles for loss and one fumble recovery. He had two stuffs against Atlanta on Oct. 10.

How to make Colts vs. Jets picks

For Thursday Night Football, Hartstein is leaning over the point total, and he also has identified a critical X-factor that makes one side of the spread a must-back. He's sharing what it is, and which side to back, only at SportsLine.

Who wins Jets vs. Colts on Thursday Night Football? And what critical x-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Jets vs. Colts spread you need to jump on, all from the expert who returned more than $1,000 to $100 players in the last 30 Indianapolis games, and find out.