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Hunter Brown, the top prospect in the Houston Astros organization, makes his major league debut on Labor Day when he takes the mound for the Astros against the Texas Rangers at Minute Maid Park in Houston. A fifth round pick in the 2019 MLB Draft, Brown was dominant in the Pacific Coast League this season, with a 2.55 ERA, 1.08 WHIP, .186 batting average against and 134 strikeouts in 106 innings. On Monday he squares off against the Rangers' Martin Perez. Houston is a -170 favorite (risk $170 to win $100) in the latest MLB odds from Caesars Sportsbook while Texas is a +143 underdog. First pitch is set for 7:10 p.m. ET. 

The game is one of 13 on the MLB schedule for Labor Day. Elsewhere in the majors, the Blue Jays and Orioles play a crucial doubleheader in Baltimore, and the Dodgers and Giants renew their rivalry in Los Angeles. Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is a 311-271 on top-rated MLB money-line picks since the start of the 2021 season. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win the World Series. Anybody who has followed the model has seen profitable returns.

Now, the model has locked in four confident MLB best bets for Monday. They all involve games at 6:40 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of almost 17-1. You can only see the model's MLB picks at SportsLine

Top MLB picks today

After simulating every game on Labor Day 10,000 times, the model likes the Over 8 runs (-110) in the Rangers vs. Astros game. Five of the last six meetings between the teams have gone Over the total, with all five featuring at least eight runs scored. In the last two games that Perez has started for the Rangers, the teams have combined for 20 runs; both games went Over the total.

In addition, Jose Altuve is red-hot at the plate for the Astros. Over his last five games, the former American League MVP is 10-of-21 (.476 batting average) with two home runs and six RBI. In 53 career at-bats against Perez, Altuve is batting .302 with a .823 OPS. See who else to back right here.

Featured Game | Houston Astros vs. Texas Rangers

How to make MLB picks and parlays for Labor Day

The model also locked in three other best bets for Monday, including a play on a big underdog. You can see the model's MLB Monday best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of almost 17-1? And which underdog is the model all over? Visit SportsLine now to see the MLB best bets from an advanced model that is 311-271 on top-rated MLB money-line picks since the start of the 2021 season.