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Justin Verlander and the Houston Astros will try to continue their dominance Friday night as they host the Seattle Mariners as part of a 15-game MLB schedule. Verlander leads MLB with 13 victories and is third with a 1.86 ERA, and he will try to lead the Astros to a fifth straight win against their AL West rivals. Houston increased its lead to 11 games over second-place Seattle in the division with a 4-2 win Thursday night. Elsewhere, an intriguing three-game interleague series kicks off between the Minnesota Twins, first in the AL Central, and the San Diego Padres, second in the NL West. The Cleveland Guardians are just two games behind the Twins in the Central but 2.5 behind the Tampa Bay Rays Rays in the AL Wild-Card race. Cleveland has a chance to make up that deficit starting Friday, as the teams open a three-game series at Tropicana Field at 7:10 p.m. ET.

First pitch at Minute Maid Park is set for 8:10 p.m. ET. Houston is a -178 favorite (risk $178 to win $100) in the latest MLB odds from Caesars Sportsbook, with Seattle a +150 underdog. The Twins vs. Padres matchup is set for 9:40 p.m. ET, and San Diego is a -130 favorite at Caesars. The 15-game Friday MLB schedule offers plenty of wagering options, and if you combine your favorite plays into a parlay, you can really cash in. Before making any MLB picks or setting up any parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is 284-243 on top-rated MLB money-line picks since the start of the 2021 season, returning over $400 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns. 

Now, the model has locked in four confident MLB best bets for Friday. They all involve games at 8:10 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of more than 8-1. You can see the model's MLB picks only at SportsLine

Top MLB picks today

One pick the model is strongly backing Friday is Twins +1.5 runs (-210) against the Padres. San Diego has played a lot of close games, ranking third in MLB with 50 save opportunities, and the bullpen has blown 16 of those. The model has the Twins covering 65 percent of the time -- and winning outright in 41 percent of its simulations. Given the pitching matchup and Padres bullpen problems, Minnesota should stay close if not win outright.

Twins rookie right-hander Joe Ryan (7-3, 2.89 ERA) is scheduled to start opposite San Diego lefty Blake Snell (2-5, 4.75). That looks like a clear edge for Minnesota, especially when you consider that Ryan has allowed just 13 hits and five runs in 22 innings over his past four starts, Snell walks more than five batters per game, while Ryan averages fewer than two, so the Twins should get plenty of men on base. The model's predicted score shows just a half-run difference.

Featured Game | San Diego Padres vs. Minnesota Twins

How to make MLB picks and parlays for Friday

The model has locked in three other best bets for Friday, including one favorite that is winning in nearly 70 percent of simulations, and they all can help you earn a huge payday if you parlay the picks. You can only see the model's MLB parlay picks and best bets for Friday night at SportsLine.

Which MLB picks should you target for Friday in a parlay offering a payout of more than 8-1? And which team is winning outright in nearly 70 percent of simulations and is a must-back? Visit SportsLine now to see the MLB best bets for Friday from the model that is 284-243 on top-rated MLB money-line picks since the start of the 2021 season.